Vu, Nguyen Nghia Tran, Thi Thu Thuy Giang, Phan Minh Kawakami, Susumu Otsuka, Hideaki Hoang, Thi Minh Nguyet Lee, Jae Wook Cong, Pham Van Trinh, Thi Thu Huong 2026-05-07T09:30:17Z 2026-05-07T09:30:17Z 2026-05-07 2026-03 1478-6419 https://pubs.kist.re.kr/handle/201004/154647 A new tetraflavonoid, named multifloraflavone (1), along with garcinol (2), isogarcinol (3), aromadendrin (4), and morelloflavone (5) were isolated from the fruit pericarp of Garcinia multiflora collected in Vietnam. The three-dimensional arrangements of groups in this complex molecule were analysed using NOESY and CD spectroscopic methods. Compounds 1-5 were evaluated for their antioxidant, acetylcholinesterase inhibitory, and anti-Helicobacter pylori activities. Multifloraflavone (1) exhibited the strongest antioxidant activity in the DPPH scavenging assay (IC50 = 3.90 & micro;M), surpassing the standard quercetin. Aromadendrin (4) and morelloflavone (5) displayed potent acetylcholinesterase inhibitory effects (IC50 = 0.66 and 1.13 & micro;M, respectively), approaching the efficacy of the reference drug donepezil (IC50 = 0.076 & micro;M). Notably, compounds 1 and 3-5 exhibited activity against H. pylori strains. Compound 4, with MIC values of 0.1-0.5 mg/mL, showed the strongest inhibition against a H. pylori HP-6.250224 clinical isolate strain, which is resistant to amoxicillin, metronidazole, and clarithromycin. English Taylor & Francis Multifloraflavone and polyphenols from Garcinia multiflora with antioxidant, anti-acetylcholinesterase, and anti-Helicobacter pylori activities Article 10.1080/14786419.2026.2647365 1 Natural Product Research Natural Product Research N scie scopus 2-s2.0-105034321625 Chemistry, Applied Chemistry, Medicinal Chemistry Pharmacology & Pharmacy Article; Early Access BENZOPHENONES BIFLAVONOIDS XANTHONES DERIVATIVES tetraflavonoid circular dichroism antioxidant acetylcholinesterase <italic>Helicobacter pylori</italic> <italic>Garcinia multiflora</italic>