LEE, YOUNGDEOK Yang, Jin Kyoung Han Sunmi Kim Bo Ri Shin Jung-Won Bang Joona Kim Sehoon 2024-01-12T02:30:18Z 2024-01-12T02:30:18Z 2022-11-29 2023-05 0340-3696 https://pubs.kist.re.kr/handle/201004/75735 Acne vulgaris is a common skin disease caused by multifactorial reasons involving excessive sebum secretion and inflammation by Cutibacterium acnes (C. acnes). Various conventional therapies are available for the treatment of acne vulgaris; however, topical photodynamic therapy (PDT) has attracted much attention because of its great potential for sebum-reducing, anti-inflammatory, and antimicrobial activities. Although 5-aminolevulinic acid (ALA) has been broadly used as a photosensitizer for topical PDT, it has several limitations such as long incubation time, pain, and post-inflammatory hyperpigmentation. Here, we report a biocompatible nanoformulation consisting of methylene blue and salicylic acid (MBSD), as a potent PDT and acne therapeutics, enclosed within oleic acid. Photoactivated MBSD showed antimicrobial activity against C. acnes along with long-term stability. When 24 patients with acne were treated with MBSD and light irradiation 5 times at 1-week intervals, MBSD-based PDT exhibited a remarkable reduction in acne lesions and sebum production. In addition, the therapeutic procedure was painless and safe, without any adverse events. Therefore, MBSD is a promising topical PDT agent for biocompatible, safe, and effective acne treatment. English Springer Verlag Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris Article 10.1007/s00403-022-02464-7 1 Archives of Dermatological Research, v.315, pp.885 - 893 Archives of Dermatological Research 315 885 893 N scie scopus 000883297800001 Dermatology Dermatology SOLID LIPID NANOPARTICLES 5-AMINOLEVULINIC ACID AMINOLEVULINIC-ACID PROTOPORPHYRIN MANAGEMENT UPDATE LIGHT LASER DYE Methylene blue Salicylic acid Nanoformulation Photodynamic therapy Acne vulgaris