Hwang, Kyeong Seob Seo, Eun U Choi, Nakwon Kim, Jongbaeg Kim, Hong Nam 2024-01-12T02:31:56Z 2024-01-12T02:31:56Z 2022-11-21 2023-03 2452-199X https://pubs.kist.re.kr/handle/201004/75790 Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage. Depending on the infection route and virus type, infectious diseases are classified as respiratory, nervous, immune, digestive, or skin infections. Since these infectious diseases can widely spread in the com-munity and their catastrophic effects are severe, identification of their causative agent and mechanisms un-derlying their pathogenesis is an urgent necessity. Although infection-associated mechanisms have been studied in two-dimensional (2D) cell culture models and animal models, they have shown limitations in organ-specific or human-associated pathogenesis, and the development of a human-organ-mimetic system is required. Recently, three-dimensional (3D) engineered tissue models, which can present human organ-like physiology in terms of the 3D structure, utilization of human-originated cells, recapitulation of physiological stimuli, and tight cell-cell interactions, were developed. Furthermore, recent studies have shown that these models can recapitulate infection-associated pathologies. In this review, we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections. First, we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection pathology. Next, we provided an overview of recently reported viral infection models, focusing particularly on organ-specific infection pathologies. Finally, a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented. English Elsevier 3D engineered tissue models for studying human-specific infectious viral diseases Article 10.1016/j.bioactmat.2022.09.010 1 Bioactive Materials, v.21, pp.576 - 594 Bioactive Materials 21 576 594 Y scie scopus 000888640200001 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Review HUMAN-PAPILLOMAVIRUS INFECTION HUMAN NOROVIRUS INFECTION NEURAL PROGENITOR CELLS HERPES-SIMPLEX VIRUS-1 MOUSE MODEL JAPANESE ENCEPHALITIS CEREBRAL ORGANOIDS CHIKUNGUNYA VIRUS INFLUENZA-VIRUS RESPIRATORY SYNCYTIAL VIRUS Pathology Invivo-mimicking 3D engineered tissue model Infectious viral disease Infection route