Thangam, Ramar
Kim, Seong Yeol
Kang, Nayeon
Hong, Hyunsik
Lee,HyunJeong
Lee, Sungkyu
Jeong, Daun
Tag, Kyong ryol
KIM KANGHYEON
Zhu, Yangzhi
Sun, Wujin
Kim, HanJun
Cho, SeungWoo
Ahn, Jae Pyoung
Jang, Woo Young
Kim, Jong Seung
Paulmurugan, Ramasamy
Khademhosseini, Ali
Kim, Hong-Kyu
Kang, Heemin
2024-01-12T02:32:34Z
2024-01-12T02:32:34Z
2023-01-20
2023-02
1616-301X
https://pubs.kist.re.kr/handle/201004/75817
In natural microenvironment, various proteins containing adhesive ligands in fibrous and non-fibrous structures dynamically couple and decouple to
regulate stem cell fate. Herein, materials presenting movably couplable ligands are developed by grafting liganded gold nanoparticles (AuNPs) to a
substrate followed by flexibly grafting liganded movable linear nanomaterials (MLNs) to the substrate via a long bendable linker, thereby creating a
space between the MLNs and the AuNPs in the decoupled state. Magnetic control of the MLNs decreases this space via the bending of the linker to
couple the MLNs to the AuNPs. Remote control of ligand coupling stimulates integrin recruitment to the coupled ligands, thereby non-toxically
facilitating the focal adhesion, mechanosensing, and potential differentiation of stem cells, which is suppressed by ligand decoupling. Versatile
tuning of size, aspect ratio, distributions, and ligands of the MLNs can help to decipher dynamic ligand-coupling-dependent stem cell fate to advance
regenerative therapies
English
John Wiley & Sons Ltd.
Ligand Coupling and Decoupling Modulates Stem Cell Fate
Article
10.1002/adfm.202206673
1
Advanced Functional Materials, v.33, no.8
Advanced Functional Materials
33
8
N
scie
scopus
000916620600001
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
Article
EXTRACELLULAR-MATRIX
ADHESION
DIFFERENTIATION
FIBRONECTIN
COLLAGEN
IMPACT
ORDER
ligand coupling
dynamic nanorods
integrin binding
stem cell adhesions
stem cell fate