Lee, Dahae LeeSangHyuk Lee, Heesu Choi, You-Kyung Kang, Ki Sung Lee, Jae Wook 2024-01-12T02:33:32Z 2024-01-12T02:33:32Z 2023-01-07 2023-01 0960-894X https://pubs.kist.re.kr/handle/201004/75858 This study aimed to explore the renoprotective effects of oxime derivatives against cisplatin-mediated cell death in LLC-PK1 porcine kidney epithelial cells. Treatment with compounds 161-A and 161-F improved cisplatin-mediated LLC-PK1 cell damage and increased cell viability by more than 80% of the control value when compared with that of cisplatin-treated cells. In addition, 161-A and 161-F reduced cisplatin-induced apoptosis. Analysis of the molecular mechanisms underlying the effects exerted by these compounds revealed that treatment with 161-A and 161-B inhibited the protein expression of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) and cleaved caspase-3 in cisplatin-treated LLC-PK1 cells. Thus, these findings provide in vitro scientific evidence that oxime derivatives may be useful as pharmacological candidates for the prevention of cisplatin-mediated nephrotoxicity. English Pergamon Press Ltd. Elucidation of protective effects of oxime derivatives against cisplatin-induced cytotoxicity in LLC-PK1 kidney cells Article 10.1016/j.bmcl.2022.129114 1 Bioorganic & Medicinal Chemistry Letters, v.80 Bioorganic & Medicinal Chemistry Letters 80 N scie scopus 000913961400001 Chemistry, Medicinal Chemistry, Organic Pharmacology & Pharmacy Chemistry Article INDUCED NEPHROTOXICITY MECHANISMS ANALOGS AGENTS Oxime derivatives LLC-PK1 cells Nephrotoxicity cisplatin Apoptosis