Jo SeongHoon Sun, In-Cheol Ahn, Cheol-Hee Lee, Sangmin Kim, Kwang meyung 2024-01-12T02:33:52Z 2024-01-12T02:33:52Z 2022-06-15 2023-01 1944-8244 https://pubs.kist.re.kr/handle/201004/75872 In view of the fact that the blood-brain barrier (BBB) prevents the transport of imaging probes and therapeutic agents to the brain and thus hinders the diagnosis and treatment of brain-related disorders, methods of circumventing this problem (e.g., ultrasound-mediated nano-particle delivery) have drawn much attention. Among the related techniques, focused ultrasound (FUS) is a favorite means of enhancing drug delivery via transient BBB opening. Photoacoustic brain imaging relies on the conversion of light into heat and the detection of ultrasound signals from contrast agents, offering the benefits of high resolution and large penetration depth. The extensive versatility and adjustable physicochemical properties of nano-particles make them promising therapeutic agents and imaging probes, allowing for successful brain imaging and treatment through the combined action of ultrasound and nanoparticulate agents. FUS-induced BBB opening enables nanoparticle-based drug delivery systems to efficiently access the brain. Moreover, photoacoustic brain imaging using nanoparticle-based contrast agents effectively visualizes brain morphologies or diseases. Herein, we review the progress in the simultaneous use of nanoparticles and ultrasound in brain research, revealing the potential of ultrasound-mediated nanoparticle delivery for the effective diagnosis and treatment of brain disorders. English American Chemical Society Recent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment Article 10.1021/acsami.1c22803 1 ACS Applied Materials & Interfaces, v.15, no.1, pp.120 - 137 ACS Applied Materials & Interfaces 15 1 120 137 N scie scopus 000823609400001 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Review SEMICONDUCTING POLYMER NANOPARTICLES GUIDED FOCUSED ULTRASOUND CONVECTION-ENHANCED DELIVERY DRUG-DELIVERY BARRIER DISRUPTION LIPOSOMAL DOXORUBICIN PARKINSONS-DISEASE THERMAL ABLATION PENETRATING NANOPARTICLES PHOTOACOUSTIC TOMOGRAPHY blood-brain barrier focused ultrasound photoacoustic imaging nanoparticles brain