반츠라크치 Haneul Ju 노주원 함정엽 Kim, Jin-Chul 2024-01-12T02:34:11Z 2024-01-12T02:34:11Z 2022-12-02 2022-12 2072-6643 https://pubs.kist.re.kr/handle/201004/75886 Goat’s beard (Aruncus dioicus var. kamtschaticus) is a traditional medicinal plant, widely used in Chinese and Korean traditional medicine because of its anti-inflammatory, anti-oxidant, antimicrobial, and anti-cancer activity. However, its effect on skin inflammatory diseases like psoriasis is unknown. The aim of this study was to investigate the therapeutic potency of A. dioicus extract (ADE) in in vitro and in vivo psoriasis models. ADE treatment significantly attenuated skin inflammation and improved skin integrity in imiquimod-treated mice by suppressing keratinocyte hyperproliferation, inhibiting the infiltration of immune cells, and downregulating the expression of psoriatic markers. Further, ADE treatment suppressed protein kinase B/mammalian target of rapamycin (Akt/mTOR) and Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) signaling in HaCaT cells. Overall, the application of ADE relieves psoriasis-like skin inflammation possibly by regulating the Akt/mTOR and JAK2/STAT3 signaling pathways, making it an effective alternative for psoriasis therapy. English Multidisciplinary Digital Publishing Institute (MDPI) Aruncus dioicus var. kamtschaticus Extract Ameliorates Psoriasis-like Skin Inflammation via Akt/mTOR and JAK2/STAT3 Signaling Pathways in a Murine Model Article 10.3390/nu14235094 1 Nutrients, v.14, no.23 Nutrients 14 23 Y scie scopus 000897437900001 Nutrition & Dietetics Nutrition & Dietetics Article IMIQUIMOD-INDUCED PSORIASIS IN-VITRO CYTOKINES MICE DISEASES Aruncus dioicus var. kamtschaticus psoriasis keratinocytes imiquimod