홍성철 YuHyungSeok 김진우 이은하 판철호 Hong Kwang Won 김진철 2024-01-12T02:35:06Z 2024-01-12T02:35:06Z 2022-11-30 2022-11 2045-2322 https://pubs.kist.re.kr/handle/201004/75925 Dry eye syndrome (DES) affects the cornea, causes pain and hypersensitivity to light. Although inflammation and endoplasmic reticulum stress are known to be involved, the detailed mechanisms remain unknown. DES is characterized by a decrease in corneal thickness, tear volume, and lacrimal gland size, and damage to corneal cells. Tisochrysis lutea is a microalga that has been shown to reduce immune factors. Therefore, we hypothesized that T. lutea could ameliorate DES. We investigated the role of T. lutea in scopolamine-induced DES in BALB/c mice. Oral administration of T. lutea increased corneal thickness, tear volume, and size of the corneal cells, and reduced damage to the corneal cells. Furthermore, treatment of ARPE-19 human retinal pigmented epithelial cells with T. lutea reduced expression of the inflammatory factor, NF-kappa B, MAPK, and AKT. T. lutea may be used therapeutically to reduce the symptoms of DES. English Nature Publishing Group Protective effect of Tisochrysis lutea on dry eye syndrome via NF-kappa B inhibition Article 10.1038/s41598-022-23545-7 1 Scientific Reports, v.12, no.1 Scientific Reports 12 1 Y scie scopus 000885139000055 Multidisciplinary Sciences Science & Technology - Other Topics POLYUNSATURATED FATTY-ACIDS DEPRESSION DISEASE ANXIETY PUFA ASSOCIATION POPULATION SYMPTOMS PATHWAYS THERAPY