Park, InWha Park, Goeun choi yoojin Jo, Seung-Woo Kwon, Hak Cheol Park, Jin-Soo Cha, Jin Wook 2024-01-12T02:35:36Z 2024-01-12T02:35:36Z 2022-11-09 2022-11 2076-3921 https://pubs.kist.re.kr/handle/201004/75947 With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed via a free radical mechanism could be used to modulate the radical-scavenging ability of natural products as well as involve structural change. As the health benefits of radicals are also presented, there is a need for a controllable radical scavenging method for topical and selective application. In this study, we developed a novel acquisition and processing method to identify light-controlled radical scavengers in plant extracts and evaluate their antioxidant activity under light irradiation based on in situ UV-LED NMR spectroscopy. Using the developed method, licochalcones A and B, in which the trans and cis isomers undergo reversible photoisomerization, were selectively identified from licorice root extract, and their light-induced free radical scavenging activity was confirmed. English MDPI AG Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy Article 10.3390/antiox11112206 1 Antioxidants, v.11, no.11 Antioxidants 11 11 Y scie scopus 000883359200001 Biochemistry & Molecular Biology Chemistry, Medicinal Food Science & Technology Biochemistry & Molecular Biology Pharmacology & Pharmacy Food Science & Technology Article PHOTOISOMERIZATION ANTIOXIDANTS RESVERATROL MECHANISM free radical scavenger in situ NMR spectroscopy natural products photoisomerization