Choi, Gwang Jin Yoo, Hyun Ji Cho, YoonKyung Shim, Shinyong Yun, Seunghyeon Sung, Jaehoon Lim, Yoonseob Jun, Sang Beom Kim, Sung June 2024-01-12T02:36:32Z 2024-01-12T02:36:32Z 2022-10-31 2022-10 1741-2560 https://pubs.kist.re.kr/handle/201004/75986 Objective. Connectors for implantable neural prosthetic systems provide several advantages such as simplification of surgery, safe replacement of implanted devices, and modular design of the implant systems. With the rapid advancement of technologies for neural implants, miniaturized multichannel implantable connectors are also required. In this study, we propose a reconnectable and area-efficient multichannel implantable connector. Approach. A female-to-female adapter was fabricated using the thermal-press bonding of micropatterned liquid crystal polymer films. A bump inside the adapter enabled a reliable electrical connection by increasing the contact pressure between the contact pads of the adapter and the inserted cable. After connection, the adapter is enclosed in a metal case sealed with silicone elastomer packing. With different sizes of the packings, leakage current tests were performed under accelerated conditions to determine the optimal design for long-term reliability. Repeated connection tests were performed to verify the durability and reconnectability of the fabricated connector. The connector was implanted in rats, and the leakage currents were monitored to evaluate the stability of the connector in vivo. Main results. The fabricated four- and eight-channel implantable connectors, assembled with the metal cases, had a diameter and length of 6 and 17 mm, respectively. Further, the contact resistances of the four- and eight-channel connectors were 53.2 and 75.2 mΩ, respectively. The electrical contact remained stable during repeated connection tests (50 times). The fabricated connectors with packings having 125%, 137%, and 150% volume ratios to the internal space of the metal case failed after 14, 88, and 14 d, respectively, in a 75 °C saline environment. In animal tests with rats, the connector maintained low leakage current levels for up to 92 d. Significance. An implantable and reconnectable multichannel connector was developed and evaluated. The feasibility of the proposed connector was evaluated in terms of electrical and mechanical characteristics as well as sealing performance. The proposed connector is expected to have potential applications in implantable neural prosthetic systems. English Institute of Physics Publishing Development of a miniaturized, reconnectable, and implantable multichannel connector Article 10.1088/1741-2552/ac99ff 1 Journal of Neural Engineering, v.19, no.5 Journal of Neural Engineering 19 5 Y scie scopus 000877843100001 Engineering, Biomedical Neurosciences Engineering Neurosciences & Neurology Article HIGH-DENSITY CONNECTOR NEURAL PROBE STIMULATION MEMBRANES DESIGN ARRAYS PDMS implantable connector liquid crystal polymer neural implant