Nguyen Thi Kim An Nguyen, Bao Ngoc Hoang, Thi Minh Nguyet Doan, Lan Phuong Pahn Minh Giang Lee, Heesu Kim Dae Won Lee, Jae Wook Thuy, Thi Thu Thuy 2024-01-12T03:00:08Z 2024-01-12T03:00:08Z 2022-08-22 2022-09 1612-1872 https://pubs.kist.re.kr/handle/201004/76618 Six new polyoxygenated xanthones, garcicowanones F？H (1-3), norcowanol A？B (4-5), andgarcinone F (6) along with twelve known compounds 7？18 were obtained from the latex of Garcinia cowa Roxb.ex Choisy. All new compounds have a 1,3,7-trioxygenatedor 1,3,6,7-tetra oxygenate dxanthonenucleus and differ from majority of xanthones from G. cowa by hydratedsidechains. Compounds1,7,8 and 18 exhibited significant neuroprotective effects on glutamate-mediated hippocampal neuronal HT22 cell death. In particular,compound1 exhibited the most potent neuroprotective effect with >80% cell viability in the concentration range of 2.9？115μM. Further studies on compound1 showed that it decreased cellular Ca2+ influx and inhibits cellular reactive oxygen species generation in HT22 cells. A Western blot analysis showed that MAPK phosphorylation, Bax, and AIF translocation dramatically increased upon treatment with 5 mM glutamate and decreased upon a co-treatment with compound1 English Verlag Helvetica Chimica Acta Six New Polyoxygenated Xanthones from Garcinia cowa and Their Neuroprotective Effects on Glutamate-Mediated Hippocampal Neuronal HT22 Cell Death Article 10.1002/cbdv.202200376 1 Chemistry & Biodiversity, v.19, no.9 Chemistry & Biodiversity 19 9 N scie scopus 000842700700001 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article TETRAOXYGENATED XANTHONES CHEMICAL-CONSTITUENTS PRENYLATED XANTHONES CYCLE ARREST DERIVATIVES APOPTOSIS LEAVES FRUITS TWIGS PHLOROGLUCINOL Garcinia cowa polyoxygenated xanthones neuroprotective HT22 cell