Kim, Hyoseok Ko, Sooho Park, Keunwan Lim, Yong-beom 2024-01-12T03:00:58Z 2024-01-12T03:00:58Z 2022-08-09 2022-08 1022-1352 https://pubs.kist.re.kr/handle/201004/76646 Despite the high prevalence and functional significance of nonregular assemblies in biology, little attention has been given to realize them in artificial systems. Here, the discovery of general principles underlying the formation of nonregular objects is described by chemical self-assembly. The cell-shaped assemblies (CSAs) are characterized by a main body comprising a nonregular vesicle and dendritically shaped spiky projections. The major mechanisms of CSA morphogenesis are: first, polycrystalline structures consisting of grains and grain boundaries induce the formation of nonregular objects by promoting nonuniform supramolecular crystal growth. Second, the fibrous nanostructures in 2D networks and in 1D bundles firmly support the main body and the spiky projections, respectively. This study also shows that there exist certain connections among entirely disparate entities, that is, organic supramolecular assemblies, inorganic materials, and cells regarding their fundamental principles of building block organizations. The principle behind the CSA formation can be applied to control the dynamic and mechanical properties of self-assembled materials. English John Wiley & Sons Ltd. Morphogenesis of Cell-Shaped Assemblies via Heterotypic Assembly of Cyclic Triblock Peptides Article 10.1002/macp.202200103 1 Macromolecular Chemistry and Physics, v.223, no.16 Macromolecular Chemistry and Physics 223 16 N scie scopus 000815613200001 Polymer Science Polymer Science Article NANOPARTICLES TRYPTOPHAN DYNAMICS DESIGN PH coassembly grain boundaries heterotypic assembly nonregular objects self-sorting