choi, ji woong Sun, In-Cheol Hwang, Hee Sook Yoon, Hong Yeol Kim, Kwang meyung 2024-01-12T03:01:50Z 2024-01-12T03:01:50Z 2022-06-15 2022-07 0169-409X https://pubs.kist.re.kr/handle/201004/76680 Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. Furthermore, functional photodynamic nanomedicines have enabled overcoming oxygen depletion during photodynamic therapy (PDT) and tissue light penetration limitation by supplying oxygen or upconverting light in targeted tumor tissues, resulting in providing the potential to overcome biological therapeutic barriers of PDT. Nevertheless, their localized therapeutic effects still remain a huddle for the effective treatment of metastatic- or recurrent tumors. Recently, newly designed photodynamic nanomedicines and their combination chemo- or immune checkpoint inhibitor therapy enable the systemic treatment of various metastatic tumors by eliciting antitumor immune responses via immunogenic cell death (ICD). This review introduces recent advances in photodynamic nanomedicines and their applications, focusing on overcoming current limitations. Finally, the challenges and future perspectives of the clinical translation of photodynamic nanomedicines in cancer PDT are discussed. (C) 2022 Elsevier B.V. All rights reserved. English Elsevier BV Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment Article 10.1016/j.addr.2022.114344 1 Advanced Drug Delivery Reviews, v.186, pp.114344 Advanced Drug Delivery Reviews 186 114344 N scie scopus 000821343200008 Pharmacology & Pharmacy Pharmacology & Pharmacy Review HYALURONIC-ACID NANOPARTICLES METAL-ORGANIC FRAMEWORKS IN-VIVO SINGLET OXYGEN DRUG-DELIVERY CERENKOV RADIATION PRODRUG MICELLES ANTICANCER DRUG ENERGY-TRANSFER CHLORIN E6 Light-triggered nanomedicine Tumor microenvironment Photodynamic therapy Photodynamic imaging Photodynamic immunotherapy