Kim, Jae Kwan Ahn, Wonbin Park, Sangin Lee, Soo-Hong Kim, Laehyun 2024-01-12T03:32:38Z 2024-01-12T03:32:38Z 2022-03-02 2022-02 1661-7827 https://pubs.kist.re.kr/handle/201004/76801 Sepsis is a life-threatening condition with a high mortality rate. Early prediction and treatment are the most effective strategies for increasing survival rates. This paper proposes a neural architecture search (NAS) model to predict the onset of sepsis with a low computational cost and high search performance by applying a genetic algorithm (GA). The proposed model shares the weights of all possible connection nodes internally within the neural network. Externally, the search cost is reduced through the weight-sharing effect between the genotypes of the GA. A predictive analysis was performed using the Medical Information Mart for Intensive Care III (MIMIC-III), a medical time-series dataset, with the primary objective of predicting sepsis onset 3 h before occurrence. In addition, experiments were conducted under various prediction times (0-12 h) for comparison. The proposed model exhibited an area under the receiver operating characteristic curve (AUROC) score of 0.94 (95% CI: 0.92-0.96) for 3 h, which is 0.31-0.26 higher than the scores obtained using the Sequential Organ Failure Assessment (SOFA), quick SOFA (qSOFA), and Simplified Acute Physiology Score (SAPS) II scoring systems. Furthermore, the proposed model exhibited a 12% improvement in the AUROC value over a simple model based on the long short-term memory neural network. Additionally, it is not only optimally searchable for sepsis onset prediction, but also outperforms conventional models that use similar predictive purposes and datasets. Notably, it is sufficiently robust to shape changes in the input data and has less structural dependence. English Multidisciplinary Digital Publishing Institute (MDPI) Early Prediction of Sepsis Onset Using Neural Architecture Search Based on Genetic Algorithms Article 10.3390/ijerph19042349 1 International Journal of Environmental Research and Public Health, v.19, no.4 International Journal of Environmental Research and Public Health 19 4 Y scie ssci scopus 000765529800001 2-s2.0-85124893280 Environmental Sciences Public, Environmental & Occupational Health Environmental Sciences & Ecology Public, Environmental & Occupational Health Article SAPS-II DEFINITIONS REPRESENTATIONS VALIDATION genetic algorithm intensive care unit neural architecture search sepsis