Hong, Sung-Chul Yu Hyung-Seok Lee, Eun Ha Hong, Chi-Rac Choi, Jaeyoung Lee, Juchan Chang, Pahn-Shick Kim, Jin-Chul 2024-01-12T03:41:08Z 2024-01-12T03:41:08Z 2022-07-12 2022-07-08 https://pubs.kist.re.kr/handle/201004/77151 Liposomes are one of the most intensively studied type of lipid nanovesicles. Liposomes increase the bioavailability of insoluble or poorly soluble materials, hence offering a wide range of food applications. In spite of such advantage, the use of liposome has been constrained by the fact that a toxic organic solvent is required during the manufacturing process to disperse the emulsifier. To this end, an environmentally friendly solvent-based liposome manufacturing system was developed and optimized. It was selected that a non-toxic solvent capable of dispersing phospholipids. Additionally, it was determined that the significant variables affecting the processing efficiency of liposomes using the Plackett-Burman (PB) design and the Response Surface Method (RSM) to optimize the process for mass production. As a result, liposomes with size and dispersion stability of approximately 180 nm and ？ 58 mV were obtained. Additionally, cells were treated with liposomes containing functional materials that is unstable or insoluble in water. In results, bioavailability was more than doubled in cell experiments compared to a functional material treatment. English 한국식품과학회 Optimization of Environmentally Friendly Solvent-based Liposome Manufacturing System to Increase Bioavailability with Functional Materials Conference 2 2022 한국식품과학회 국제학술대회 및 정기총회 2022 한국식품과학회 국제학술대회 및 정기총회 KO 부산 벡스코 2022-07-06 2022 한국식품과학회 국제학술대회 및 정기총회 초록집