You Bin Cho Hyunbeom Lee Hui-Jeon Jeon Jae Yeol Lee KIM, HYOUNG JA 2024-01-12T06:30:28Z 2024-01-12T06:30:28Z 2024-01-11 2024-01 https://pubs.kist.re.kr/handle/201004/79669 In our search for bioactive components, various chromatographic separations of the organic fractions from Filipendula glaberrima leaves led to the isolation of a new ellagitannin and a triterpenoid, along with 26 known compounds. The structures of the isolates were determined based on their spectroscopic properties and chemical evidence, which were then evaluated for their antioxidant activities, inhibitory activities on 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and foam cell formation in THP-1 cells to prevent atherosclerosis. Rugosin B methyl ester (1) showed the best HMG-CoA reductase inhibition and significantly reduced ox-low-density lipoprotein-induced THP-1 macrophage-derived foam cell formation at 25 ？M. In addition, no cytotoxicity was observed in THP-1 cells at 50 μg/mL of all extracts in the macrophage foam cell formation assay. Therefore, F. glaberrima extract containing 1 is promising in the development of dietary supplements due to its potential behavior as a novel source of nutrients for preventing and treating atherosclerosis. English Multidisciplinary Digital Publishing Institute (MDPI) Antioxidant and Inhibitory Activities of Filipendula glaberrima Leaf Constituents against HMG-CoA Reductase and Macrophage Foam Cell Formation Article 10.3390/molecules29020354 1 Molecules, v.29, no.2 Molecules 29 2 Y scie scopus 001152865500001 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Article TANNINS POLYPHENOLS GLYCOSIDES TRITERPENOIDS FLAVONOIDS PLANTS Filipendula glaberrima antioxidant activity 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) foam cell formation hydrolysable tannins atherosclerosis