Cho, Suyeon Kim, Yejin Hwang, Ho Seong Kwon, Yu jin Son, So-Ri Jong gwon Baek Park, InWha Kang, Yoon Jin Rhee, Hyungjin Kwon, Hak Cheol Kwon, Jaeyoung Kim, Won Kyu Jang, Dae Sik 2024-01-12T06:31:29Z 2024-01-12T06:31:29Z 2023-11-22 2023-12 https://pubs.kist.re.kr/handle/201004/79703 Diffuse-type gastric cancer (GC) is a type of stomach cancer that occurs in small clusters of cells that are widely spread. It does not typically manifest with symptoms until the advanced stages and often goes undetected in routine imaging tests. In addition, there is no specific targeted therapy for diffuse-type GC and it has a high mortality risk. Hence, it is worthwhile to discover molecules against this cancer. In this study, the extract of Heloniopsis koreana, which is endemic to Korea, exhibited cytotoxicity against two diffuse-type GC cell lines, MKN1 and SNU668. This led to the isolation of 10 compounds, including a new cinnamic acid glycoside. Of the compounds, saponin Th (4) and SNF 11 (5) showed potent activities with IC50 values of 3.66 and 3.85 μM, respectively, in MKN1 cells, and 1.8 and 1.98 μM, respectively, in SNU668 cells. These compounds prevented cancer cell division, invasion, and colony formation in both cell lines. In addition, these compounds induced cancer cell death through conventional cell death pathways, showing an increase in ADP-ribose polymerase, caspase 3, and BAX and a decrease in BCL2. English ACS Publications Saponins Derived from the Korean Endemic Plant Heloniopsis koreana Inhibit Diffuse-type Gastric Cancer Cells Article 10.1021/acsomega.3c06714 1 ACS Omega, v.8, no.50, pp.48019 - 48027 ACS Omega 8 50 48019 48027 Y scie scopus 001128515100001 Chemistry, Multidisciplinary Chemistry Article