Koo, Sagang Sohn, Hee Su Kim Tae Hee Siyeon Yang Jang, Seyoun Ye, Seongryeol Choi, Boomin Kim, Soo Hyeon Park, Kyoung Sun Shin, Hyun Mu Park, Ok Kyu Kim, Cheesue Kang, Mikyung Soh, Min Jin, Yoo Kim, Dokyoon Lee, Nohyun Kim, Byung-Soo Jung, Young Mee Hyeon, Taeghwan 2024-01-12T06:31:38Z 2024-01-12T06:31:38Z 2023-11-17 2023-12 1748-3387 https://pubs.kist.re.kr/handle/201004/79710 Commencing with the breakdown of immune tolerance, multiple pathogenic factors, including synovial inflammation and harmful cytokines, are conjointly involved in the progression of rheumatoid arthritis. Intervening to mitigate some of these factors can bring a short-term therapeutic effect, but other unresolved factors will continue to aggravate the disease. Here we developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to address multiple factors in rheumatoid arthritis. Each component of this nanohybrid works individually and also synergistically, resulting in comprehensive treatment. Alleviation of inflammation and modulation of the tissue environment into an immunotolerant-favourable state are combined to recover the immune system by bridging innate and adaptive immunity. The therapy is shown to successfully treat and prevent rheumatoid arthritis by relieving the main symptoms and also by restoring the immune system through the induction of regulatory T cells in a mouse model of collagen-induced arthritis. English Nature Publishing Group Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model Article 10.1038/s41565-023-01523-y 1 Nature Nanotechnology, v.18, no.12, pp.1502 - 1514 Nature Nanotechnology 18 12 1502 1514 N scie scopus 001087973500001 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article REGULATORY T-CELLS RHEUMATOID-ARTHRITIS T(H)17