Park, Mijeong Ha, Jimin Lee, Yuri Choi, Hoon-Seong Kim, Byoung Soo Jeong, Youn Kyoung 2024-01-12T06:31:52Z 2024-01-12T06:31:52Z 2023-09-19 2023-12 0197-4580 https://pubs.kist.re.kr/handle/201004/79721 The anti-inflammatory efficacy of radiation therapy (RT) with single fractions below 1.0 Gy has been demonstrated in Alzheimer’s disease mouse models. As neuroinflammation is also a major pathological feature of Parkinson’s disease (PD), RT may also be effective in PD treatment. Therefore, this study aimed to investigate the anti-inflammatory effect of low-moderate dose RT (LMDRT, 0.6 Gy/single dose, for 5 days) exposure in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, i.p., for 5 consecutive days)-induced PD mouse model. Importantly, LMDRT reduced the levels of glial fibrillary acidic protein (GFAP) and intercellular adhesion molecule-1 (ICAM-1, CD54) in the striatum region, which increased following MPTP administration. LMDRT also modulated inflammatory gene expression patterns in the substantia nigra region of the MPTP-treated mice. However, LMDRT had no direct effects on the severe loss of dopaminergic neurons and impaired motor behavior in the rotarod test. These results indicate that LMDRT has anti-inflammatory effects by modulating neuroinflammatory factors, including GFAP and ICAM-1, but showed no behavioral improvements or neuroprotection in the MPTP-induced mouse model of PD. English Elsevier BV Low-moderate dose whole-brain γ-ray irradiation modulates the expressions of GFAP and ICAM-1 in the MPTP-induced Parkinson’s disease mouse model Article 10.1016/j.neurobiolaging.2023.06.015 1 Neurobiology of Aging, v.132, pp.175 - 184 Neurobiology of Aging 132 175 184 Y scie scopus 001106776400001 Geriatrics & Gerontology Neurosciences Geriatrics & Gerontology Neurosciences & Neurology Article RADIATION-THERAPY SUBACUTE MPTP ANIMAL-MODEL NEUROINFLAMMATION MECHANISMS LEVODOPA ICAM-1 MICE INFLAMMATION ACTIVATION Low-moderate dose radiation therapy Parkinson&apos s disease Neuroinflammation GFAP ICAM-1 (CD54)