Kim, Joonki Lee, Sang Heon Zhang, Siqi Bong SimKyu Kim, Aaron Taehwan Lee, Hara Liu, Xiaoyong Kim, Sang Moo Kim, Su-Nam 2024-01-12T06:32:55Z 2024-01-12T06:32:55Z 2023-11-06 2023-11 1467-3037 https://pubs.kist.re.kr/handle/201004/79773 Asthma is a chronic inflammatory disease involving structural changes to the respiratory system and severe immune responses mediated by allergic cytokines and pro-inflammatory mediators. Agarum cribrosum (AC) is a kind of seaweed which contains a phlorotannin, trifuhalol A. To evaluate its anti-allergic inflammatory effect against asthma, an ovalbumin inhalation-induced mouse asthma model was used. Histologic observations proved that trifuhalol A is minimizing the lung and tracheal structure changes as well as the infiltration of eosinophils and mast cells against ovalbumin inhalation challenge. From the serum and bronchoalveolar lavage fluid, ovalbumin-specific IgE and Th2-specific cytokines, IL-4, -5, and -13, were reduced with trifuhalol A treatment. In addition, IL-1β, IL-6, and TNF-α concentrations in lung homogenate were also significantly reduced via trifuhalol A treatment. Taken together, trifuhalol A, isolated from AC, was able to protect lung and airways from Th2-specific cytokine release, and IgE mediated allergic inflammation as well as the attenuation of IL-1β, IL-6, and TNF-α in lung, which results in the suppression of eosinophils and the mast cells involved asthmatic pathology. English MDPI Anti-Allergic Inflammatory Effect of Agarum cribrosum and Its Phlorotannin Component, Trifuhalol A, against the Ovalbumin-Induced Allergic Asthma Model Article 10.3390/cimb45110557 1 Current Issues in Molecular Biology, v.45, no.11, pp.8882 - 8893 Current Issues in Molecular Biology 45 11 8882 8893 Y scie scopus 001123317400001 Biochemistry & Molecular Biology Biochemistry & Molecular Biology Article CYTOKINES EOSINOPHILS INTERLEUKIN-4 PATHOGENESIS AIRWAYS ALPHA CELLS Agarum cribrosum trifuhalol A asthma allergic ovalbumin inflammation