Lee Ga hyun Kim Do Wook JIN YUN HUI Kim, Sang Min Lim, Eui Seok Cha Minji Ko, Ja Kyong Gong, Gyeong taek Lee, Sun-Mi Um, Young soon Han, Sung Ok Ahn, Jung Ho 2024-01-12T06:33:25Z 2024-01-12T06:33:25Z 2023-10-31 2023-10 1661-6596 https://pubs.kist.re.kr/handle/201004/79797 Various kinds of plastics have been developed over the past century, vastly improving the quality of life. However, the indiscriminate production and irresponsible management of plastics have led to the accumulation of plastic waste, emerging as a pressing environmental concern. To establish a clean and sustainable plastic economy, plastic recycling becomes imperative to mitigate resource depletion and replace non-eco-friendly processes, such as incineration. Although chemical and mechanical recycling technologies exist, the prevalence of composite plastics in product manufacturing complicates recycling efforts. In recent years, the biodegradation of plastics using enzymes and microorganisms has been reported, opening a new possibility for biotechnological plastic degradation and bio-upcycling. This review provides an overview of microbial strains capable of degrading various plastics, highlighting key enzymes and their role. In addition, recent advances in plastic waste valorization technology based on systems metabolic engineering are explored in detail. Finally, future perspectives on systems metabolic engineering strategies to develop a circular plastic bioeconomy are discussed. English Multidisciplinary Digital Publishing Institute (MDPI) Biotechnological Plastic Degradation and Valorization Using Systems Metabolic Engineering Article 10.3390/ijms242015181 1 International Journal of Molecular Sciences, v.24, no.20 International Journal of Molecular Sciences 24 20 Y scie scopus 001089732800001 Biochemistry & Molecular Biology Chemistry, Multidisciplinary Biochemistry & Molecular Biology Chemistry Review ESCHERICHIA-COLI POLY(L-LACTIDE) DEGRADATION POLY(BUTYLENE SUCCINATE) PSEUDOMONAS-AERUGINOSA POLYESTER POLYURETHANE ANTIBACTERIAL ACTIVITY ENZYMATIC DEGRADATION ACID) DEPOLYMERASE POLYLACTIC ACID GALLIC ACID plastic waste biodegradation bio-upcycling circular plastic bioeconomy systems metabolic engineering