Keasler, Kaitlyn T. Zick, Mary E. Stacy, Emily E. Kim, Jaehwan Lee, Jung-Hoon Aeindartehran, Lida Run？evski, Tom？e Milner, Phillip J. 2024-01-12T06:34:02Z 2024-01-12T06:34:02Z 2023-11-21 2023-09 0036-8075 https://pubs.kist.re.kr/handle/201004/79826 Fluorine is an increasingly common substituent in pharmaceuticals and agrochemicals because it improves the bioavailability and metabolic stability of organic molecules. Fluorinated gases represent intuitive building blocks for the late-stage installation of fluorinated groups, but they are generally overlooked because they require the use of specialized equipment. We report a general strategy for handling fluorinated gases as benchtop-stable solid reagents using metal-organic frameworks (MOFs). Gas-MOF reagents are prepared on gram-scale and used to facilitate fluorovinylation and fluoroalkylation reactions. Encapsulation of gas-MOF reagents within wax enables stable storage on the benchtop and controlled release into solution upon sonication, which represents a safer alternative to handling the gas directly. Furthermore, our approach enables high-throughput reaction development with these gases. English American Association for the Advancement of Science Handling fluorinated gases as solid reagents using metal-organic frameworks Article 10.1126/science.adg8835 1 Science, v.381, no.6665, pp.1455 - 1461 Science 381 6665 1455 1461 N scie scopus 001100656800038 Multidisciplinary Sciences Science & Technology - Other Topics Article CROSS-COUPLING REACTIONS ARYLBORONIC ACIDS FACILE SYNTHESIS ADSORPTION TRIFLUOROMETHYLATION FUNCTIONALIZATION GENERATION SEPARATION ALDEHYDES DENSITY