Jae-Seung Moon Chun-Chang Ho Park, Jong Hyun Kyungsoo Park Bo-Young Shin Su-Hyeon Lee Ines Sequeira Chin Hee Mun Jin-Su Shin Jung-Ho Kim Beom Seok Kim Jin-Wook Noh Eui-Seon Lee Ji Young Son Yuna Kim Yeji lee Hee Cho SunHyeon So Jiyoon Park Eunsu Choi Jong-Won Oh Sang-Won Lee Tomohiro Morio Fiona M. Watt Rho Hyun Seong Sang-Kyou Lee 2024-01-12T06:34:08Z 2024-01-12T06:34:08Z 2023-10-20 2023-09 2041-1723 https://pubs.kist.re.kr/handle/201004/79831 Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is defined by Foxp3 expression. However, the molecular determinants defining the suppressive population of T cells have yet to be discovered. Here we report that the cell surface protein Lrig1 is enriched in suppressive T cells and controls their suppressive behaviors. Within CD4+ T cells, Treg cells express the highest levels of Lrig1, and the expression level is further increasing with activation. The Lrig1+ subpopulation from T helper (Th) 17 cells showed higher suppressive activity than the Lrig1- subpopulation. Lrig1-deficiency impairs the suppressive function of Treg cells, while Lrig1-deficient na？ve T cells normally differentiate into other T cell subsets. Adoptive transfer of CD4+Lrig1+ T cells alleviates autoimmune symptoms in colitis and lupus nephritis mouse models. A monoclonal anti-Lrig1 antibody significantly improves the symptoms of experimental autoimmune encephalomyelitis. In conclusion, Lrig1 is an important regulator of suppressive T cell function and an exploitable target for treating autoimmune conditions. English Nature Publishing Group Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis Article 10.1038/s41467-023-40986-4 1 Nature Communications, v.14, no.1 Nature Communications 14 1 Y scie scopus 001072382600012 2-s2.0-85169672692 Multidisciplinary Sciences Science & Technology - Other Topics Article REGULATORY T-CELLS ERBB NEGATIVE REGULATOR CD127 EXPRESSION FOXP3 EXPRESSION TH17 CELLS IN-VITRO ACTIVATION LRIG1 EXPANSION IDENTIFICATION