Park, Hana Jung, MinSun Choi, Shinai Cho, Yoeseph Sung, Chang min Min, Ho phil Kim, Ki Hun Bahn, Yong-Sun SON, Jung hyun 2024-01-12T06:34:30Z 2024-01-12T06:34:30Z 2023-07-12 2023-09 0889-1575 https://pubs.kist.re.kr/handle/201004/79847 Ricinine, a toxic compound found in castor plants (Ricinus communis), causes abdominal pain, nausea, and vomiting. Castor leaves and castor oil-based dietary supplements are commonly consumed, but their ricinine content has not been evaluated for safety. This study aimed to determine the ricinine concentration in these products and to evaluate the ricinine exposure level from their consumption. The developed method combines the Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) technique and liquid chromatography？tandem mass spectrometry (LC？MS/MS). A matrix-matched calibration method for castor leaves is then proposed, which demonstrates high linearity over a wide concentration range (50？1000 ？g/kg; r2 > 0.995). The intraday and interday accuracies ranged from 93.6% to 113.7%; the precisions were within 10%. The limits of detection and quantitation were ≤ 8.9 ？g/kg and ≤ 26.9 ？g/kg, respectively, and this validated method was successfully applied to commercial castor plant-based products. Ricinine exposure from the consumption of these foods was estimated to be 0.0001？0.2792 ？g/kg body weight/day. This study assesses the safety of castor plant-based food products and could help prevent potential health risks associated with ricinine consumption. English Academic Press Monitoring and exposure assessment of ricinine in castor plant-based foods and dietary supplements Article 10.1016/j.jfca.2023.105484 1 Journal of Food Composition and Analysis, v.122 Journal of Food Composition and Analysis 122 Y scie scopus 001030092100001 Chemistry, Applied Food Science & Technology Chemistry Food Science & Technology Article HUMAN URINE BIOMARKER QUANTIFICATION SPECTROMETRY FEED ACID Ricinine LC-MS MS QuEChERS Method validation Monitoring Exposure assessment Castor leaves Food Dietary supplements Plant toxin