Seo, Sung Eun Kim, Kyung Ho Ha, Siyoung Oh, Hanseul Kim, Jinyeong Kim, Soomin Kim, Lina SEO, MIN AH An, Jai Eun Park, Yoo Min Lee, Kyoung G. Kim, Yu Kyung Kim, Woo­Keun Hong, Jung Joo Song, Hyun Seok Kwon, Oh Seok 2024-01-12T06:34:59Z 2024-01-12T06:34:59Z 2023-11-23 2024-03 0935-9648 https://pubs.kist.re.kr/handle/201004/79872 The transmission and pathogenesis of highly contagious fatal respiratory viruses are increasing, and the need for an on-site diagnostic platform has arisen as an issue worldwide. Furthermore, as the spread of respiratory virus continues, different variants have become the dominant circulating strains. To prevent virus transmission, the development of highly sensitive and accurate on-site diagnostic assays is urgently needed. Herein, we present a facile diagnostic device for multi-detection based on the results of detailed receptor？ligand dynamics simulations for the screening of various viral strains. Our novel bioreceptor？treated electronics (receptonics) device consists of a multichannel graphene transistor and cell-entry receptors conjugated to N-heterocyclic carbene (NHC). We achieved ultrasensitive multi-detection performance without the need for sample pretreatment, which will enable rapid diagnosis and prevent the spread of pathogens. This platform can be applied for the diagnosis of variants of concern in clinical respiratory virus samples and primate models. Our multi-screening platform can be used to enhance surveillance and discriminate emerging virus variants before they become a severe threat to public health. English WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Synchronous diagnosis of respiratory viruses variants via receptonics based on modeling receptor-ligand dynamics Article 10.1002/adma.202303079 1 Advanced Materials, v.36, no.9 Advanced Materials 36 9 N scie scopus 001124880500001 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article RAMAN-SPECTROSCOPY ACE2 RECEPTOR SARS-COV-2 INFECTION field-effect transistors interfacing chemistry portable devices receptonics respiratory viruses