Kim, Taehyun Kim, Jinwoo Min, Huitae Park Jisu 김태정 김근형 박병준 김정국 Park, Young Tae 김진철 Ham, Jung yeob 2024-01-12T06:35:36Z 2024-01-12T06:35:36Z 2023-09-18 2023-06 1598-642X https://pubs.kist.re.kr/handle/201004/79902 Cannabis sativa (CS) has been in the spotlight not only for its medical uses but also as a raw material for cosmetics. As fermented cosmetics are known to have various health benefits, they have been extensively researched. Here, we investigated the characteristics of CS stems fermented using various gut microbes. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay and melanin content analysis revealed that melan-a cells containing CS stems fermented with Weissella paramesenteroides (CSWP) showed considerably reduced melanin content. Additionally, CSWP downregulated the expression of several melanogenesis factors, tyrosinase-related protein-1, and tyrosinase-related protein-2. This study suggests that the anti-melanogenic effect of CSWP could provide a new basis for the development of skin-lightening agents. English 한국미생물·생명공학회 Anti-Melanogenic Effect of Cannabis sativa Stem Extracts Fermented with Weissella paramesenteroides Article 10.48022/mbl.2303.03012 1 Microbiology and Biotechnology Letters, v.51, no.2, pp.1 - 7 Microbiology and Biotechnology Letters 51 2 1 7 N scopus kci ART003003172 Cannabis sativa fermentation Weissella paramesenteroides anti-melanogenesis