Huang, Tianqi Zhao, Dong Lee, Sang Bin Keum, Gyochang Yang, Hyun Ok 2024-01-12T06:36:29Z 2024-01-12T06:36:29Z 2023-02-18 2023-05 1976-9148 https://pubs.kist.re.kr/handle/201004/79946 Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved in the development progress of neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease. The objective of this study was to investigate the effect of SA in microglia neuroinflammation models. Our results demonstrated that SA inhibited secretion of the nitric oxide (NO) and interleukin (IL)-6, reduced the expression of inducible nitric oxide synthase (iNOS) and enhanced the release of IL-10 in a dose-dependent manner. Besides, our further investigation revealed that SA attenuated the phosphorylation of AKT and MAPK cascades in LPS-induced microglia. Consistently, oral administration of SA in mouse regulated the production of inflammationrelated cytokines and also suppressed the phosphorylation of MAPK cascades and AKT in the mouse cerebral cortex. These results suggested that SA may be a possible therapy candidate for anti-inflammatory activity by targeting the AKT/MAPK signaling pathway. English 한국응용약물학회 Sinapic Acid Attenuates the Neuroinflammatory Response by Targeting AKT and MAPK in LPS-Activated Microglial Models Article 10.4062/biomolther.2022.092 1 Biomolecules & Therapeutics, v.31, no.3, pp.276 - 284 Biomolecules & Therapeutics 31 3 276 284 N scie scopus kci ART002951793 000986546400003 Biochemistry & Molecular Biology Pharmacology & Pharmacy Biochemistry & Molecular Biology Pharmacology & Pharmacy Article Sinapic acid Neuroinflammation BV-2 microglia Anti-inflammation MAPK/AKT signaling pathway