https://pubs.kist.re.kr/handle/123456789/75356 2026-04-05T01:09:11Z 2026-04-05T01:09:11Z Peng, HR Kim, DI Sarkaria, JN Cho, YS Abraham, RT Zalkow, LH https://pubs.kist.re.kr/handle/201004/139904 2024-04-26T08:36:44Z 2002-01-01T00:00:00Z

Title: Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases Authors: Peng, HR; Kim, DI; Sarkaria, JN; Cho, YS; Abraham, RT; Zalkow, LH Abstract: Several pyrrolo-quinoline gamma -lactones were found as novel inhibitors for two members of the PI3-kinase related kinase (PIKK) family, Ataxia-Telangiectasia-mutated (ATM) protein and the mammalian Target of Rapamycin (mTOR). Preliminary structure-activity relationship studies indicated that an electrophilic exocyclic double bond conjugated to the carbonyl group of the gamma -lactone ring was crucial for the PIKK inhibitory potency. One of the best ATM inhibitors in this series, DK8G557, showed IC50 values of 0.6 and 7.0 muM for ATM and mTOR, respectively. This compound exhibited potent and selective growth inhibition activities in the NCI 60 human tumor cell line screen with a GI(50) MG-MID value of 2.69 muM. The best mTOR inhibitor in this series, HP9912, exhibited IC50 values of 0.5 and 6.5 muM for mTOR and ATM, respectively. These compounds suggest novel leads for the discovery of potent small molecule inhibitors of PIKKs as potential anticancer drugs, with therapeutic activities as either single, or as sensitizing agents to conventional radio-, or chemo-therapeutic strategies. (C) 2001 Elsevier Science Ltd. All rights reserved.

2002-01-01T00:00:00Z Yoo, BW Choi, KH Lee, SJ Yoon, CM Kim, SH Kim, JH https://pubs.kist.re.kr/handle/201004/139903 2024-04-26T08:36:41Z 2002-01-01T00:00:00Z

Title: Mild and efficient reduction of sulfoxides to sulfides with bis(cyclopentadienyl)titanium(IV) dichloride-indium system Authors: Yoo, BW; Choi, KH; Lee, SJ; Yoon, CM; Kim, SH; Kim, JH Abstract: CP2TiCl2/In system was found to be a new reagent for reducing various sulfoxides to the corresponding sulfides in good yields under mild and neutral conditions.

2002-01-01T00:00:00Z Lee, DY Jin, JS Kang, BH https://pubs.kist.re.kr/handle/201004/139902 2024-04-26T08:36:39Z 2002-01-01T00:00:00Z

Title: Momentum boundary layer and its influence on the convective heat transfer in porous media Authors: Lee, DY; Jin, JS; Kang, BH Abstract: Convective heat transfer in a channel filled with a porous medium has been analyzed in this paper. The flow field is analyzed considering both the inertia and solid boundary effects and the thickness of the momentum boundary layer is found as a function of the Darcy and the Reynolds number. The two-equation model is applied for the heat transfer analysis and theoretical solutions are obtained for both fluid and solid phase temperature fields. The Nusselt number is obtained in terms of the relevant physical parameters, such as the Biot number for the internal heat exchange, the ratio of effective conductivities between the fluid and solid phases, and the thickness of the momentum boundary layer. The results indicate that the influence of the velocity profile is characterized within two regimes according to the two parameters, the Biot number and the conductivity ratio between the phases. The decrease in the heat transfer due to the momentum boundary layer is 15% at most within a practical range of the pertinent parameters. (C) 2001 Elsevier Science Ltd. All rights reserved.

2002-01-01T00:00:00Z Kim, JH Lee, SH Ahn, JH Lee, JK https://pubs.kist.re.kr/handle/201004/139901 2024-04-26T08:36:37Z 2002-01-01T00:00:00Z

Title: AlN piezoelectric materials for wireless communication thin film components Authors: Kim, JH; Lee, SH; Ahn, JH; Lee, JK Abstract: A Bragg reflector type FBAR using AIN piezoelectric with quarter wavelength thickness has been fabricated, where the Bragg reflector was composed of W-SiO2 pairs. By numerical simulation, considering actual acoustic losses of each layer, an analysis of the frequency response of the resonator has been made and this could be explained using an equivalent circuit with parasitic elements. The Effective electromechanical coupling constant (K-eff(2)) and the Quality factor (Q(s)), figures of merit of the resonator, were about 1.1% and 307, respectively.

2002-01-01T00:00:00Z