https://pubs.kist.re.kr/handle/123456789/75360 2026-04-15T18:22:22Z 2026-04-15T18:22:22Z Kim, EJ Chung, MY Chung, HJ Son, MW Kwon, JW Yoo, M Lee, MG https://pubs.kist.re.kr/handle/201004/135875 2024-04-26T01:36:51Z 2006-01-01T00:00:00Z

Title: Pharmacokinetics of 7-carboxymethyloxy-3 ',4 ',5-trimethoxy flavone (DA-6034), a derivative of flavonoid, in mouse and rat models of chemically-induced inflammatory bowel disease Authors: Kim, EJ; Chung, MY; Chung, HJ; Son, MW; Kwon, JW; Yoo, M; Lee, MG Abstract: The pharmacokinetics (including distribution in the gastrointestinal tract) of 7-carboxymethyloxy-3',4',5-trimethoxy flavone (DA-6034) has been investigated in several mouse and rat models of chemically-induced inflammatory bowel disease (IBD). In the female ICR mouse model, IBD was induced by dextran sulfate and the mice administered 30 mg kg(-1) DA-6034 intravenously or orally. In the male SJL mouse model of IBD induced by oxazolone, 30 mg kg(-1) DA-6034 was administered orally. In the male Sprague-Dawley rat model of IBD induced by trinitrobenzene sulfonic acid (TNBS), 10 mg kg(-1) DA-6034 was administered intravenously and orally. After intravenous administration, the total area under the plasma concentration-time curve from time zero to the last measured time, t, in plasma (AUC(0-t)) values were comparable between control and dextran sulfate-induced IBD mice, and between control and TNBS-induced rats. This suggested that the disposition of DA-6034 was not affected considerably by dextran sulfate in mice and TNBS in rats. However, after oral administration in mice and rats with IBD, the AUC(0-t) values were greater compared with the respective controls. This could have been due to an increase (slow) in the gastrointestinal transit time (in IBD mice and rats, the percentages of the oral dose recovered from the rinsing fluid of the small intestine and large intestine as unchanged drug were greater and smaller, respectively), and an increase in intestinal permeability.

2006-01-01T00:00:00Z Lee, SJ Noh, SK Hong, SC Lee, JI https://pubs.kist.re.kr/handle/201004/135874 2024-04-26T01:36:49Z 2006-01-01T00:00:00Z

Title: Normal-incidence far-infrared detectivity of InAs/GaAs QDIPs doped in dots and barriers Authors: Lee, SJ; Noh, SK; Hong, SC; Lee, JI Abstract: We report some comparative results on the normal-incidence device characteristics accomplished with a couple of self-assembled InAs/GaAs quantum-dot infrared photodetectors (QDIPs) doped in InAs QDs and GaAs barriers. The peak values of responsivity and detectivity for the barrier-doped device are 650 mA/W and 3.2 x 10(8) cm Hz(1/2)/W (18 K) at lambda(p) congruent to 5 mu m, respectively, which are approximately two and ten times higher than those for the QD-doped one. In addition, while there is no spectral response over 6 pm in the QD-doped structure, a strong photoresponse is extended up to around 10 pm in the barrier-doped one. Although the direct doping in InAs QDs is effective for blocking the dark current, the doping in GaAs barriers has better device performance of QDIP. (c) 2005 Elsevier B.V. All rights reserved.

2006-01-01T00:00:00Z Kim, SJ Kim, EJ Kang, TB Jung, KD Joo, OS Shin, CH https://pubs.kist.re.kr/handle/201004/135873 2024-04-26T01:36:47Z 2006-01-01T00:00:00Z

Title: Synthesis and characterization of transition metal oxide-pillared materials with mesoporosity from layered silicate ilerite Authors: Kim, SJ; Kim, EJ; Kang, TB; Jung, KD; Joo, OS; Shin, CH Abstract: Metal oxide (Ti, Fe, Zr)-pillared porous materials with various surface areas have been synthesized by the intercalation of metal organic between the layers of layered silicate ilerite. The surface areas of metal oxide-pillared ilerite materials depended significantly on pillaring time and the type and amount of pillaring metal oxide. The surface areas of Ti-, Fe- and Zr-ilerite materials were in the range of 152-338, 150-290 and 147-245 m(2)/g, respectively, depending on the pillaring condition. The results from X-ray diffraction and N-2 adsorption-desorption isotherms demonstrated that metal oxide-pillared ilerite materials possessed different pore structures from silica-pillared ilerite materials, due to the different nature of metal oxide and silica pillars. The gallery heights of Ti-, Fe- and Zr-ilerite materials were in the range of 3.55-4.05, 2.55-3.65 and 3.25-3.95 nm, respectively, which are 1-2 nm larger than that of silica-pillared ilerite materials. In addition, metal oxide-pillared ilerite materials exhibited the pore size distributions of mesoporosity. In the case of the metal oxide-pillared ilerite materials with homogeneous pore structures, the average pore diameters were in the range of about 2-5 nm, depending on the type of pillared metal oxide. Ti-ilerite materials exhibited relatively narrow range of pore size distribution. On the other hand, Fe-ilerite materials exhibited broad range of pore size distribution. The results from NH3-TPD and IR measurements revealed that the metal oxide pillaring into the interlayers of ilerite produced acid sites and new hydroxyl groups. Zr-ilerite materials possessed a broad range of acid sites from weak to medium acidity, whereas Ti-ilerite and Fe-ilerite materials had only weak acid sites.

2006-01-01T00:00:00Z Karng, SW Kwak, HY https://pubs.kist.re.kr/handle/201004/135872 2024-04-26T01:36:45Z 2006-01-01T00:00:00Z

Title: Relaxation behavior of microbubbles in ultrasonic field Authors: Karng, SW; Kwak, HY Abstract: The nonlinear oscillation of microbubbles under the influence of ultrasound was investigated experimentally and theoretically. The radius-time curves of bubbles including afterbounces calculated using the Rayleigh-Plesset equation with polytropic relations and with the Keller-Miksis equation using analytical solutions for the Navier-Stokes equations of the gases were compared with the results observed from light scattering. This study revealed that the dynamic behavior of microbubbles in an ultrasonic field, such as the expansion ratio of the maximum to the equilibrium radius and the bouncing motion after the first collapse (minimum), depends crucially on the relaxation time of the bubble motion with respect to the characteristic time of the applied ultrasound. and that the relaxation time decreases as the equilibrium radius of the microbubbles increases.

2006-01-01T00:00:00Z