https://pubs.kist.re.kr/handle/123456789/75367 2026-02-23T09:50:25Z 2026-02-23T09:50:25Z Fukui, Masayuki Kang, Ki Sung Okada, Kazushi Zhu, Bao Ting https://pubs.kist.re.kr/handle/201004/128533 2024-04-25T12:04:03Z 2013-01-01T00:00:00Z

Title: EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: Role of ROS accumulation, caspase-8 activation, and autophagy induction Authors: Fukui, Masayuki; Kang, Ki Sung; Okada, Kazushi; Zhu, Bao Ting Abstract: In a recent study, we showed that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two common omega-3 fatty acids, can cause ROS accumulation and subsequently induce caspase-8-dependent apoptosis in human breast cancer cells (Kang et al. [2010], PLoS ONE 5: e10296). In this study, we showed that the pancreas has a unique ability to accumulate EPA at a level markedly higher than several other tissues analyzed. Based on this finding, we sought to further investigate the anticancer actions of EPA and its analog DHA in human pancreatic cancer cells using both in vitro and in vivo models. EPA and DHA were found to induce ROS accumulation and caspase-8-dependent cell death in human pancreatic cancer cells (MIA-PaCa-2 and Capan-2) in vitro. Feeding animals with a diet supplemented with 5% fish oil, which contains high levels of EPA and DHA, also strongly suppresses the growth of MIA-PaCa-2 human pancreatic cancer xenografts in athymic nude mice, by inducing oxidative stress and cell death. In addition, we showed that EPA can concomitantly induce autophagy in these cancer cells, and the induction of autophagy diminishes its ability to induce apoptotic cell death. It is therefore suggested that combination of EPA with an autophagy inhibitor may be a useful strategy in increasing the therapeutic effectiveness in pancreatic cancer. J. Cell. Biochem. 114: 192203, 2012. (C) 2012 Wiley Periodicals, Inc.

2013-01-01T00:00:00Z Tueysuez, Harun Hwang, Yun Jeong Khan, Sher Bahadar Asiri, Abdullah Mohamed Yang, Peidong https://pubs.kist.re.kr/handle/201004/128532 2024-04-25T12:03:58Z 2013-01-01T00:00:00Z

Title: Mesoporous Co3O4 as an electrocatalyst for water oxidation Authors: Tueysuez, Harun; Hwang, Yun Jeong; Khan, Sher Bahadar; Asiri, Abdullah Mohamed; Yang, Peidong Abstract: Mesoporous Co3O4 has been prepared using porous silica as a hard template via a nanocasting route and its electrocatalytic properties were investigated as an oxygen evolution catalyst for the electrolysis of water. The ordered mesostructured Co3O4 shows dramatically increased catalytic activity compared to that of bulk Co3O4. Enhanced catalytic activity was achieved with high porosity and surface area, and the water oxidation overpotential (eta) of the ordered mesoporous Co3O4 decreases significantly as the surface area increases. The mesoporous Co3O4 also shows excellent structural stability in alkaline media. After 100 min under 0.8 V (versus Ag/AgCl) applied bias, the sample maintains the ordered mesoporous structure with little deactivation of the catalytic properties.

2013-01-01T00:00:00Z Getmanenko, Yulia A. Fonari, Marina Risko, Chad Sandhu, Bhupinder Galan, Elena Zhu, Lingyun Tongwa, Paul Hwang, Do Kyung Singh, Sanjeev Wang, He Tiwari, Shree Prakash Loo, Yueh-Lin Bredas, Jean-Luc Kippelen, Bernard Timofeeva, Tatiana Marder, Seth R. https://pubs.kist.re.kr/handle/201004/128530 2024-04-25T12:03:53Z 2013-01-01T00:00:00Z

Title: Benzo[1,2-b:6,5-b ']dithiophene(dithiazole)-4,5-dione derivatives: synthesis, electronic properties, crystal packing and charge transport Authors: Getmanenko, Yulia A.; Fonari, Marina; Risko, Chad; Sandhu, Bhupinder; Galan, Elena; Zhu, Lingyun; Tongwa, Paul; Hwang, Do Kyung; Singh, Sanjeev; Wang, He; Tiwari, Shree Prakash; Loo, Yueh-Lin; Bredas, Jean-Luc; Kippelen, Bernard; Timofeeva, Tatiana; Marder, Seth R. Abstract: A series of dihalo- and bis-aroyl-substituted benzo[1,2-b:6,5-b']dithiophene-4,5-diones were synthesized, and their electronic, electrochemical, and electrical properties investigated. Synthetic strategies to increase (i) the conjugation length of the base molecular structure - through introduction of thiophene units bearing electronically neutral substituents (hydrogen or alkyl groups) or strong electron-withdrawing pentafluorobenzoyl group(s) - and (ii) the electron affinity - by moving to a benzo[1,2-d:4,3-d']bis(thiazole)-4,5-dione structure - were developed. Molecular packing in the single crystal was studied by single-crystal X-ray structural analysis, and this information was subsequently used in the determination of the electronic band structures, densities of states (DOS), effective transfer integrals, and effective charge-carrier masses via density functional theory (DFT) methods. The charge-carrier transport properties of the benzo[1,2-b:6,5-b']dithiophene-4,5-dione and benzo[1,2-d:4,3-d']bis(thiazole)-4,5-dione derivatives were investigated through the fabrication and characterization of organic field-effect transistors (OFETs) via both solution-processed and vacuum-deposited films. 2,7-Bis-pentafluorobenzoyl-benzo[1,2-b:6,5-b']dithiophene-4,5-dione (10a) exhibited field-effect behavior with an average electron mobility mu(e) = 4.4 (+/- 1.7) x 10(-4) cm(2) V-1 s(-1) when the active layer was vacuum-deposited, and a larger mu(e) = 6.9 x 10(-3) cm(2) V-1 s(-1) when the active layer was solution-processed. These results are in stark contrast with the DFT-determined electronic band structure and effective mass, which indicate that the material possesses good intrinsic charge-carrier transport characteristics. The combined results reveal the importance of thin-film processing and that further processing refinements could lead to improved device performance. Only one material with benzo[1,2-d:4,3-d']bis(thiazole)-4,5-dione core, 2,7-bis-(4-n-hexyl-thiophene-2-yl)-benzo[1,2-d:4,3-d']bis(thiazole)-4,5-dione (19d), showed average mu(e) = 8.2 x 10(-5) cm(2) V-1 s(-1) in OFET with solution-processed active layer. Unexpectedly, measurable hole transport was observed for 2,7-bis-(5-n-nonyl-thiophen-2-yl)-benzo[1,2-b:6,5-b']dithiophene-4,5-dione (19b) (mu(h) = 8.5 x 10(-5) cm(2) V-1 s(-1)) and 2,6-bis-(thiophen-2-yl)-3,5-di-n-hexyl- 4H-cyclopenta[1,2-b:5,4-b']dithiophen-4-one (30a) (mu(h) = 3.7 x 10(-4) cm(2) V-1 s(-1)).

2013-01-01T00:00:00Z Quan, Jie Kim, Sang-Min Pan, Cheol-Ho Chung, Donghwa https://pubs.kist.re.kr/handle/201004/128529 2024-04-25T12:03:51Z 2013-01-01T00:00:00Z

Title: Characterization of fucoxanthin-loaded microspheres composed of cetyl palmitate-based solid lipid core and fish gelatin-gum arabic coacervate shell Authors: Quan, Jie; Kim, Sang-Min; Pan, Cheol-Ho; Chung, Donghwa Abstract: Fucoxanthin-loaded microspheres, composed of a cetyl palmitate (CP)-canola oil (CO) mixed solid lipid core and a fish gelatin-gum arabic complex coacervate shell cross-linked by tannic acid, were developed and characterized for efficient oral delivery of fucoxanthin. Two types of solid lipid-core microspheres (CP:CO = 30:70 and 50:50) in both wet and freeze-dried forms were investigated in their morphology, size, moisture content, and fucoxanthin encapsulation efficiency, in comparison with oil-core microspheres (CP:CO = 0:100). The melting and solidification of the cores were also analyzed by DSC. Compared to the oil-core microspheres, the solid lipid-core microspheres, especially of CP:CO = 50:50, exhibited greatly enhanced sustained fucoxanthin release performance under a simulated gastrointestinal condition and much stronger fucoxanthin-stabilizing capability when stored in the dark atmosphere of 0% or 51% relative humidity at 40 degrees C, although the encapsulation efficiency was lowered from 85.34% to 74.81% with the increase of the CP fraction from 0% to 50%. (c) 2012 Elsevier Ltd. All rights reserved.

2013-01-01T00:00:00Z