https://pubs.kist.re.kr/handle/123456789/75364 Tue, 14 Apr 2026 08:17:37 GMT 2026-04-14T08:17:37Z https://pubs.kist.re.kr/handle/201004/131861 Title: Different characteristics between auctioned and non-auctioned patents Authors: Lee, Yong-Gil; Lee, Ji-Hoon Abstract: In recent years, firms have increased their use of internal and external knowledge through intermediaries. Knowledge brokers match buyers and sellers in the technology marketplace as well as connect and combine existing knowledge. We discuss how financial incentives in the technology marketplace can address challenges to open innovation, and how the marketplace could make individual inventors essential contributors. And then, we identify the key determinants of intellectual-property auction bids and different characteristics of auctioned and non-auctioned patents. Relevance, the scope of patents, and other factors suggested in the literature impact patent auctions, as mediated by knowledge brokers. Fri, 01 Jan 2010 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/131861 2010-01-01T00:00:00Z https://pubs.kist.re.kr/handle/201004/131860 Title: Debinding behaviors of injection molded ceramic bodies with nano-sized pore channels during extraction using supercritical carbon dioxide and n-heptane solvent Authors: Kim, Sang Woo Abstract: Debinding behaviors related on changes in capillary pore structure during extraction with supercritical carbon dioxide and n-heptane, respectively were investigated for injection molded ceramic bodies consisting of skeleton pores of 68 nm. For the debinding processes, both debinding curves showed a square root of time dependence but significantly deviated in the middle or end period of debinding because of structural changes with pores during extraction. The debinding bodies experienced capillary changes having a debinding front separating the undebinded region with fluid state into the debinding region with pendular state in the wax-based green bodies. The debinding rate of the supercritical fluid extraction was five times higher than that of the solvent extraction because of a higher interdiffusion diffusivity and a formation of relatively large pore channels. An abrupt change of pore structures between debinded and undebinded region in the green bodies caused severe defects during the solvent extraction even at a low rate of debinding at 313.15 K, while the severity of the capillary changes was overcome during the supercritical fluid extraction and the debinded ceramic bodies were free from defects even at a high rate of debinding at 328.15 K. It is attributed to a reduction of the capillary stress developed on debinding front during the supercritical fluid extraction. (C) 2009 Elsevier B.V. All rights reserved. Fri, 01 Jan 2010 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/131860 2010-01-01T00:00:00Z https://pubs.kist.re.kr/handle/201004/131859 Title: Nanobubbles from Gas-Generating Polymeric Nanoparticles: Ultrasound Imaging of Living Subjects Authors: Kang, Eunah; Min, Hyun Su; Lee, Jaeyoung; Han, Moon Hee; Ahn, Hyung Jun; Yoon, In-Chan; Choi, Kuiwon; Kim, Kwangmeyoung; Park, Kinam; Kwon, Ick Chan Fri, 01 Jan 2010 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/131859 2010-01-01T00:00:00Z https://pubs.kist.re.kr/handle/201004/131858 Title: Self-assembled hyaluronic acid nanoparticles for active tumor targeting Authors: Choi, Ki Young; Chung, Hyunjin; Min, Kyung Hyun; Yoon, Hong Yeol; Kim, Kwangmeyung; Park, Jae Hyung; Kwon, Ick Chan; Jeong, Seo Young Abstract: Hyaluronic acid nanoparticles (HA-NPs), which are formed by the self-assembly of hydrophobically modified HA derivatives, were prepared to investigate their physicochemical characteristics and fates in tumor-bearing mice after systemic administration. The particle sizes of HA-NPs were controlled in the range of 237-424 nm by varying the degree of substitution of the hydrophobic moiety. When SCC7 cancer cells over-expressing CD44 (the receptor for HA) were treated with fluorescently labeled Cy5.5-HA-NPs, strong fluorescence signals were observed in the cytosol of these cells, suggesting efficient intracellular uptake of HA-NPs by receptor-mediated endocytosis. In contrast, no significant fluorescence signals were observed when Cy5.5-labeled HA-NPs were incubated with normal fibroblast cells (CV-1) or with excess free-HA treated SCC7 cells. Following systemic administration of Cy5.5-labeled HA-NPs with different particle sizes into a tumor-bearing mouse, their biodistribution was monitored as a function of time using a non-invasive near-infrared fluorescence imaging system. Irrespective of the particle size, significant amounts of HA-NPs circulated for two days in the bloodstream and were selectively accumulated into the tumor site. The smaller HA-NPs were able to reach the tumor site more effectively than larger HA-NPs. Interestingly, the concentration of HA-NPs in the tumor site was dramatically reduced when mice were pretreated with an excess of free-HA. These results imply that HA-NPs can accumulate into the tumor site by a combination of passive and active targeting mechanisms. (C) 2009 Elsevier Ltd. All rights reserved. Fri, 01 Jan 2010 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/131858 2010-01-01T00:00:00Z