https://pubs.kist.re.kr/handle/201004/75348 Wed, 25 Feb 2026 23:14:56 GMT 2026-02-25T23:14:56Z https://pubs.kist.re.kr/handle/201004/154347 Title: 상용 아연 음극의 제조사별 결정배향 특성과 열처리에따른 전기화학적 수명 개선 효과 분석 Authors: 김민우; 신성희; 김예원; 김형석 Abstract: 수계 아연 전지는 수지상 성장과 ZHS 부산물 축적으로 수명이 저하된다. 본 연구에서는 제조사별 상용아연 호일의 (002)면 우선 배향성을 비교하고, 열처리를 통한 과전압 안정화 효과를 분석하였다. 열처리로 인하여 (002)면 배향 저하로 ZHS 축적 및 수명 감소가 나타났다. Mon, 01 Dec 2025 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/154347 2025-12-01T00:00:00Z https://pubs.kist.re.kr/handle/201004/154346 Title: Activity-Based Protein Profiling Reveals Potential Dasatinib Targets in Gastric Cancer Authors: Choi, Kyoung-Min; Cho, Eunji; Bang, Geul; Lee, Seong-Jae; Kim, Boram; Kim, Ji-Hee; Park, Seo-Gyu; Han, Eun Hee; Chung, Young-Ho; Kim, Jin Young; Kim, Eunjung; Kim, Jae-Young Abstract: Dasatinib is a multi-target kinase inhibitor, whose targets include BCR-ABL, SRC family kinases, and various cancer kinases. The elevated SRC activity in gastric cancer (GC) has prompted the need for the therapeutic application of dasatinib in GC. We observed that the efficacy of dasatinib varied with the GC cell lines. The differential effect of dasatinib was not correlated with the basal SRC activity of each cell line. Moreover, the GC cell lines showing the strong antitumor effects of dasatinib were refractory to other SRC inhibitors, i.e., bosutinib and saracatinib, suggesting that unexpected dasatinib’s targets could exist. To profile the targets of dasatinib in GC, we performed activity-based protein profiling (ABPP) via mass spectrometry using a desthiobiotin-ATP probe. We identified 29 and 18 kinases as potential targets in dasatinib-sensitive (SNU-216, MKN-1) and -resistant (SNU-484, SNU-601) cell lines, respectively. The protein–protein interaction mapping of the differential drug targets in dasatinib-sensitive and -resistant GC using the STRING database suggested that dasatinib could target cellular energy homeostasis in the drug-sensitive GC. RNAi screening for identified targets indicated p90RSK could be a novel dasatinib target, which is important for maintaining the viability and motility of GC cells. Further functional validation of dasatinib off-target actions will provide more effective therapeutic options for GC. Tue, 01 Dec 2020 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/154346 2020-12-01T00:00:00Z https://pubs.kist.re.kr/handle/201004/154345 Title: N-Terminal Octylated Peptoid Hydrogels as 3D-Printable Cell Scaffolds and Proteolytically Robust Cargo Depots Authors: Park, Il-Soo; Cho, Younghak; Lee, Yen Jea; Daniela Gutierrez; Zuckermann, Ronald N.; Seong, Hyejeong; Kim, Jae Hong Abstract: Supramolecular hydrogels that mimic the extracellular matrix (ECM) represent promising materials for tissue engineering and drug delivery. However, conventional hydrogels formed via the self-assembly of natural or synthetic building blocks often face a trade-off between biological functionality and biochemical stability, limiting their utility in long-term or protease-rich environments. Peptoids, a class of peptide-inspired, sequence-defined polymers, offer a compelling alternative due to their exceptional proteolytic resistance and bioactivity. Despite this potential, the development of supramolecular peptoid hydrogels has been hindered by the absence of backbone hydrogen bond donors, which limits long-range ordering necessary for efficient hydrogel formation. This work describes a short peptoid functionalized at the N-terminus with an octyl chain that readily self-assembles into hydrogels. Hydrophobic interactions among pendant octyl groups promote directional peptoid packing into highly ordered nanosheets, which interconnect to form a porous hydrogel network. These hydrogels exhibit tunable viscoelasticity, shear-thinning, and self-healing properties, enabling their use as inks for extrusion-based 3D printing. They support NIH-3T3 fibroblast adhesion, spreading, and proliferation, maintaining greater than 95% cell viability over 4 days. Moreover, the hydrogels retain their macroscopic integrity under protease-rich conditions, enabling sustained cargo release and uniform cellular uptake. Together, this study demonstrates a class of supramolecular peptoid hydrogelators that integrate biocompatibility, 3D printability, and proteolytic stability, providing a versatile platform for ECM-mimetic scaffolds in regenerative medicine and long-term therapeutic delivery. Sun, 01 Feb 2026 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/154345 2026-02-01T00:00:00Z https://pubs.kist.re.kr/handle/201004/154344 Title: Effect of nanoimprint-induced structural heterogeneity on the oxidation behavior of Zr-based metallic glass Authors: Sang Tae Woo; Jee Hyuk Ahn; Seung Zeon Han; Young Sang Na; Chang, Hye Jung; Yong Ho Park; Ka Ram Lim Abstract: Thermal nanoimprint lithography was applied to Zr-based metallic glass to fabricate zirconia surfaces with tunable morphology, and subsequent thermal oxidation was used to further control the oxide thickness. Compared with the as-spun specimens, the imprinted specimens developed non-uniform oxide layers under identical heat-treatment conditions. Thermal stress-induced short-range order locally increases the interfacial energy with the amorphous oxide, thereby reducing the critical thickness for crystallization and promoting dendritic growth of tetragonal zirconia. These findings demonstrate that nanoimprint-induced structural heterogeneity critically governs the oxidation behavior and provide new guidelines for engineering durable functional oxide layers in Zr-based metallic glass. Fri, 01 May 2026 00:00:00 GMT https://pubs.kist.re.kr/handle/201004/154344 2026-05-01T00:00:00Z