A guide towards optimal detection of transient oscillatory bursts with unknown parameters

Abstract

Objectives. Recent event-based analyses of transient neural activities have characterized the oscillatory bursts as a neural signature that bridges dynamic neural states to cognition and behaviors. Following this insight, our study aimed to (1) compare the efficacy of common burst detection algorithms under varying signal-to-noise ratios and event durations using synthetic signals and (2) establish a strategic guideline for selecting the optimal algorithm for real datasets with undefined properties. Approach. We tested the robustness of burst detection algorithms using a simulation dataset comprising bursts of multiple frequencies. To systematically assess their performance, we used a metric called 'detection confidence', quantifying classification accuracy and temporal precision in a balanced manner. Given that burst properties in empirical data are often unknown in advance, we then proposed a selection rule to identify an optimal algorithm for a given dataset and validated its application on local field potentials of basolateral amygdala recorded from male mice (n=8) exposed to a natural threat. Main Results. Our simulation-based evaluation demonstrated that burst detection is contingent upon event duration, whereas accurately pinpointing burst onsets is more susceptible to noise level. For real data, the algorithm chosen based on the selection rule exhibited superior detection and temporal accuracy, although its statistical significance differed across frequency bands. Notably, the algorithm chosen by human visual screening differed from the one recommended by the rule, implying a potential misalignment between human priors and mathematical assumptions of the algorithms. Significance. Therefore, our findings underscore that the precise detection of transient bursts is fundamentally influenced by the chosen algorithm. The proposed algorithm-selection rule suggests a potentially viable solution, while also emphasizing the inherent limitations originating from algorithmic design and volatile performances across datasets. Consequently, this study cautions against relying solely on heuristic-based approaches, advocating for a careful algorithm selection in burst detection studies.