In situ, real-time, colorimetric detection of γ-hydroxybutyric acid (GHB) using self-protection products coated with chemical receptor-embedded hydrogel
- Authors
- Ha, Siyoung; Kim, Jinyeong; Park, Chul Soon; Lee, Sangwoo; Yoo, Donggon; Kim, Kyung Ho; Seo, Sung Eun; Park, Seon Joo; An, Jai Eun; Song, Hyun Seok; Bae, Joonwon; Kim, Woo-Keun; Kwon, Oh Seok
- Issue Date
- 2022-07
- Publisher
- Pergamon Press Ltd.
- Citation
- Biosensors and Bioelectronics, v.207
- Abstract
- Due to the increase in drug-facilitated sexual assault (DFSA) enabled by the illegal use of drugs, there have been constant demands for simple methods that can be used to protect oneself against crime in real life. gamma-Hy-droxybutyric acid (GHB), a central nervous system depressant, is one of the most dangerous drugs for use in DFSA because it is colorless and has slow physiological effects, which pose challenges for developing in situ, realtime GHB monitoring techniques. In this study, we developed a method for in situ colorimetric GHB detection using various self-protection products (SPPs) coated with 2-(3-bromo-4-hydroxystyryl)-3-ethylbenzothiazol-3ium iodide (BHEI) as a chemical receptor embedded in hydrogels. Additionally, smartphone-based detection offers enhanced colorimetric sensitivity compared to that of the naked eye. The developed SPPs will help address drug-facilitated social problems.
- Keywords
- DATE-RAPE DRUG; GAMMA-HYDROXYBUTYRATE; FLUORESCENT SENSOR; WINDOW; URINE; SERUM; gamma-Hydroxybutyric acid(GHB); Drug-facilitated sexual assault(DFSA); Self-protection product(SPP); In-situ colorimetric detection; Chemical receptor
- ISSN
- 0956-5663
- URI
- https://pubs.kist.re.kr/handle/201004/114928
- DOI
- 10.1016/j.bios.2022.114195
- Appears in Collections:
- KIST Article > 2022
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