In situ, real-time, colorimetric detection of γ-hydroxybutyric acid (GHB) using self-protection products coated with chemical receptor-embedded hydrogel

Authors
Ha, SiyoungKim, JinyeongPark, Chul SoonLee, SangwooYoo, DonggonKim, Kyung HoSeo, Sung EunPark, Seon JooAn, Jai EunSong, Hyun SeokBae, JoonwonKim, Woo-KeunKwon, Oh Seok
Issue Date
2022-07
Publisher
Pergamon Press Ltd.
Citation
Biosensors and Bioelectronics, v.207
Abstract
Due to the increase in drug-facilitated sexual assault (DFSA) enabled by the illegal use of drugs, there have been constant demands for simple methods that can be used to protect oneself against crime in real life. gamma-Hy-droxybutyric acid (GHB), a central nervous system depressant, is one of the most dangerous drugs for use in DFSA because it is colorless and has slow physiological effects, which pose challenges for developing in situ, realtime GHB monitoring techniques. In this study, we developed a method for in situ colorimetric GHB detection using various self-protection products (SPPs) coated with 2-(3-bromo-4-hydroxystyryl)-3-ethylbenzothiazol-3ium iodide (BHEI) as a chemical receptor embedded in hydrogels. Additionally, smartphone-based detection offers enhanced colorimetric sensitivity compared to that of the naked eye. The developed SPPs will help address drug-facilitated social problems.
Keywords
DATE-RAPE DRUG; GAMMA-HYDROXYBUTYRATE; FLUORESCENT SENSOR; WINDOW; URINE; SERUM; gamma-Hydroxybutyric acid(GHB); Drug-facilitated sexual assault(DFSA); Self-protection product(SPP); In-situ colorimetric detection; Chemical receptor
ISSN
0956-5663
URI
https://pubs.kist.re.kr/handle/201004/114928
DOI
10.1016/j.bios.2022.114195
Appears in Collections:
KIST Article > 2022
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE