Preparation of water-dispersible and biocompatible iron oxide nanoparticles for MRI agent

Abstract

Biocompatible nanocomposite of iron oxide with the bigger core size is expected to give the better MRI contrast. Water-dispersible superparamagnetic iron oxide nanoparticles (SPION-MPA) were prepared by covalent conjugation of SPION (7.5 nm) and mercaptopropionic acid (MPA) and then, transformed to biocompatible composite SPION-MPA-Dextran by physical adsorption of Dextran. Analysis of the composite is presented with TEM, SENT, DLS, and FT-IR data.