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Quercetin 7-O-Glutamate Potentiates Staphylococcus aureus to Fluoroquinolone Antibiotics

Authors
Park, Kwang-Su; Choo, Hyunah; Kim, Mi Kyoung; Chong, Youhoon
Issue Date
2016-09
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.37, no.9, pp.1515 - 1517
Abstract
The quercetin conjugate Q-7-O-Glu (5) showed inhibition of NorA efflux pump and thereby potentiation of antibacterial activity of various antibiotics against S. aureus. In particular, upon combination with 5, the fluoroquinolone antibiotics (ciprofloxacin) showed 4-times enhanced antibacterial activity against S. aureus.
Keywords
MEDIATED MULTIDRUG-RESISTANCE; FLAVONOID DIMERS; BIVALENT MODULATORS; EFFLUX; NORA; INHIBITION; TRANSPORTER; MECHANISM; MEDIATED MULTIDRUG-RESISTANCE; FLAVONOID DIMERS; BIVALENT MODULATORS; EFFLUX; NORA; INHIBITION; TRANSPORTER; MECHANISM; Quercetin conjugate; Efflux pump inhibitor; Fluoroquinolone; Staphylococcus aureus
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/123734
DOI
10.1002/bkcs.10901
Appears in Collections:
KIST Article > 2016
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