Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells
- Authors
- Park, Cheon-Soo; Ahn, Yongchel; Lee, Dahae; Moon, Sung Won; Kim, Ki Hyun; Yamabe, Noriko; Hwang, Gwi Seo; Jang, Hyuk Jai; Lee, Heesu; Kang, Ki Sung; Lee, Jae Wook
- Issue Date
- 2015-12-15
- Publisher
- Pergamon Press Ltd.
- Citation
- Bioorganic & Medicinal Chemistry Letters, v.25, no.24, pp.5705 - 5707
- Abstract
- Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved.
- Keywords
- BIOLOGICAL EVALUATION; DERIVATIVES; BIOLOGICAL EVALUATION; DERIVATIVES; Chalcone; Anticancer; HepG2; Apoptosis
- ISSN
- 0960-894X
- URI
- https://pubs.kist.re.kr/handle/201004/124622
- DOI
- 10.1016/j.bmcl.2015.10.093
- Appears in Collections:
- KIST Article > 2015
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