Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells

Authors
Park, Cheon-SooAhn, YongchelLee, DahaeMoon, Sung WonKim, Ki HyunYamabe, NorikoHwang, Gwi SeoJang, Hyuk JaiLee, HeesuKang, Ki SungLee, Jae Wook
Issue Date
2015-12-15
Publisher
Pergamon Press Ltd.
Citation
Bioorganic & Medicinal Chemistry Letters, v.25, no.24, pp.5705 - 5707
Abstract
Eight chalcone analogues were prepared and evaluated for their cytotoxic effects in human hepatoma HepG2 cells. Compound 5 had a potent cytotoxic effect. The percentage of apoptotic cells was significantly higher in compound 5-treated cells than in control cells. Exposure to compound 5 for 24 h induced cleavage of caspase-8 and -3, and poly (ADP-ribose) polymerase (PARP). Our findings suggest that compound 5 is the active chalcone analogue that contributes to cell death in HepG2 cells via the extrinsic apoptotic pathway. (C) 2015 Elsevier Ltd. All rights reserved.
Keywords
BIOLOGICAL EVALUATION; DERIVATIVES; BIOLOGICAL EVALUATION; DERIVATIVES; Chalcone; Anticancer; HepG2; Apoptosis
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/124622
DOI
10.1016/j.bmcl.2015.10.093
Appears in Collections:
KIST Article > 2015
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