Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp UT1123 and their protective effect to HT-22 neuronal cells

Abstract

New phenazine derivatives with a methylamine linker, Pontemazines A (1) and B (2), were isolated from the culture broth of Streptomyces sp. UT1123. The structures of compounds 1 and 2 were determined by NMR spectroscopy and high-resolution mass spectrometry. These compounds consist of a 9-mehoxyphenazine connected to a benzamide functional group by a unique methylamine linker instead of the more common methyl ether. Pontemazines A and B possess a neuronal cell protective effect on glutamate-induced mouse hippocampal HT-22 cell damage. (C) 2015 Elsevier Ltd. All rights reserved.