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dc.contributor.authorJo, Seongil-
dc.contributor.authorWoo, Hae Dong-
dc.contributor.authorKwon, Ho-Jang-
dc.contributor.authorOh, Se-Young-
dc.contributor.authorPark, Jung-Duck-
dc.contributor.authorHong, Young-Seoub-
dc.contributor.authorPyo, Heesoo-
dc.contributor.authorPark, Kyung Su-
dc.contributor.authorHa, Mina-
dc.contributor.authorKim, Ho-
dc.contributor.authorSohn, Seok-Joon-
dc.contributor.authorKim, Yu-Mi-
dc.contributor.authorLim, Ji-Ae-
dc.contributor.authorLee, Sang-Ah-
dc.contributor.authorEom, Sang-Yong-
dc.contributor.authorKim, Byoung-Gwon-
dc.contributor.authorLee, Kyoung-Mu-
dc.contributor.authorLee, Jong-Hyeon-
dc.contributor.authorHwang, Myung Sil-
dc.contributor.authorKim, Jeongseon-
dc.date.accessioned2024-01-20T06:32:38Z-
dc.date.available2024-01-20T06:32:38Z-
dc.date.created2021-09-04-
dc.date.issued2015-08-
dc.identifier.issn1661-7827-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/125194-
dc.description.abstractMethylmercury is well known for causing adverse health effects in the brain and nervous system. Estimating the elimination constant derived from the biological half-life of methylmercury in the blood or hair is an important part of calculating guidelines for methylmercury intake. Thus, this study was conducted to estimate the biological half-life of methylmercury in Korean adults. We used a one-compartment model with a direct relationship between methylmercury concentrations in the blood and daily dietary intake of methylmercury. We quantified the between-person variability of the methylmercury half-life in the population, and informative priors were used to estimate the parameters in the model. The population half-life of methylmercury was estimated to be 80.2 +/- 8.6 days. The population mean of the methylmercury half-life was 81.6 +/- 8.4 days for men and 78.9 +/- 8.6 days for women. The standard deviation of the half-life was estimated at 25.0 +/- 8.6 days. Using the direct relationship between methylmercury concentrations in blood and methylmercury intake, the biological half-life in this study was estimated to be longer than indicated by the earlier studies that have been used to set guideline values.-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.subjectPOLYUNSATURATED FATTY-ACIDS-
dc.subjectMETHYL MERCURY-
dc.subjectFISH CONSUMPTION-
dc.subjectBLOOD-
dc.subjectEXPOSURE-
dc.subjectHUMANS-
dc.subjectHAIR-
dc.subjectVARIABILITY-
dc.subjectINGESTION-
dc.titleEstimation of the Biological Half-Life of Methylmercury Using a Population Toxicokinetic Model-
dc.typeArticle-
dc.identifier.doi10.3390/ijerph120809054-
dc.description.journalClass1-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v.12, no.8, pp.9054 - 9067-
dc.citation.titleINTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH-
dc.citation.volume12-
dc.citation.number8-
dc.citation.startPage9054-
dc.citation.endPage9067-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000360587800028-
dc.identifier.scopusid2-s2.0-84938535661-
dc.relation.journalWebOfScienceCategoryEnvironmental Sciences-
dc.relation.journalWebOfScienceCategoryPublic, Environmental & Occupational Health-
dc.relation.journalResearchAreaEnvironmental Sciences & Ecology-
dc.relation.journalResearchAreaPublic, Environmental & Occupational Health-
dc.type.docTypeArticle-
dc.subject.keywordPlusPOLYUNSATURATED FATTY-ACIDS-
dc.subject.keywordPlusMETHYL MERCURY-
dc.subject.keywordPlusFISH CONSUMPTION-
dc.subject.keywordPlusBLOOD-
dc.subject.keywordPlusEXPOSURE-
dc.subject.keywordPlusHUMANS-
dc.subject.keywordPlusHAIR-
dc.subject.keywordPlusVARIABILITY-
dc.subject.keywordPlusINGESTION-
dc.subject.keywordAuthorbiological half-life-
dc.subject.keywordAuthordietary exposure-
dc.subject.keywordAuthormethylmercury-
dc.subject.keywordAuthorone-compartment toxicokinetic model-
dc.subject.keywordAuthorpopulation model-
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