Think Modular: A Simple Apoferritin-Based Platform for the Multifaceted Detection of Pancreatic Cancer

Authors
Hwang, Mintai P.Lee, Jong-WookLee, Kyung EunLee, Kwan Hyi
Issue Date
2013-09
Publisher
AMER CHEMICAL SOC
Citation
ACS NANO, v.7, no.9, pp.8167 - 8174
Abstract
The generation of nanosized probes often requires time-intensive and application-specific optimization processes that involve conjugating a nanoconstruct to a targeting moiety. Herein, we genetically modify apoferritin and generate a universal interface system composed of protein G and 6x His-tag. The resulting construct, conferred with modularity and high targeting efficiency, is applied toward two distinct applications in the detection of a pancreatic cancer biomarker and used to demonstrate its potential in the facile exchange of nanoprobe components.
Keywords
STREPTOCOCCAL PROTEIN-G; QUANTUM DOTS; CRYSTAL-STRUCTURE; TAGGED PROTEINS; FERRITIN GENES; IGG-BINDING; NANOPARTICLES; FRAGMENT; COMPLEX; BIOMARKERS; STREPTOCOCCAL PROTEIN-G; QUANTUM DOTS; CRYSTAL-STRUCTURE; TAGGED PROTEINS; FERRITIN GENES; IGG-BINDING; NANOPARTICLES; FRAGMENT; COMPLEX; BIOMARKERS; apoferritin; modular; quantum dot; gold nanoparticle; pancreatic cancer
ISSN
1936-0851
URI
https://pubs.kist.re.kr/handle/201004/127727
DOI
10.1021/nn403465a
Appears in Collections:
KIST Article > 2013
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