심혈관계 이식물용 생분해성 고분자의 세포 독성 및 급성 염증반응

Abstract

Biodegradable polymers have been used to develop cardiovascular prostheses such as vascular grafts and stents. However,thrombosis, inflammation, and restenosis that are associated with implants are still major obstacles for the use of these devices. The lack of endothelial cell (EC) lining (endothelialization) and the response of immune systems to the stents have been associated with these complications. In addition, several clinical studies have focused on the early markers or initiators of the inflammatory response in coronary stenting. The clinical reports demonstrated that some inflammatory markers, C-reactive protein (CRP), interlukin-6 (IL-6), and interlukin-1 (IL-1) exhibited relative rise in 10minutes after inserting stent. Therefore, we have examined the cell viability and the expression levels of IL-6 after treating smooth muscle cell (SMC) with the degradation product of poly(L-lactide) (PLLA) and poly(D,L-lactide-co-glycolide)(PLGA) containing sirolimus (SRL) drug.