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Nanocrystals for the parenteral delivery of poorly water-soluble drugs

Authors
Sun, Bo; Yeo, Yoon
Issue Date
2012-12
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE, v.16, no.6, pp.295 - 301
Abstract
Nanocrystals have drawn increasing interest in pharmaceutical industry because of the ability to improve dissolution of poorly water-soluble drugs. Nanocrystals can be produced by top-down and bottom-up technologies and have been explored for a variety of therapeutic applications. Here we review the methods of nanocrystal production and parenteral applications of nanocrystals. We also discuss remaining challenges in the development of nanocrystal products. (C) 2012 Elsevier Ltd. All rights reserved.
Keywords
PHASE-I TRIAL; TISSUE DISTRIBUTION; INTRAPERITONEAL DOCETAXEL; ORIDONIN NANOSUSPENSION; ANTITUMOR EFFICACY; EUDRAGIT RS100(R); TOP-DOWN; FORMULATION; PHARMACOKINETICS; PERITONEAL; PHASE-I TRIAL; TISSUE DISTRIBUTION; INTRAPERITONEAL DOCETAXEL; ORIDONIN NANOSUSPENSION; ANTITUMOR EFFICACY; EUDRAGIT RS100(R); TOP-DOWN; FORMULATION; PHARMACOKINETICS; PERITONEAL; Nanocrystals; Nanosuspension; Parenteral applications; Poorly water-soluble drugs
ISSN
1359-0286
URI
https://pubs.kist.re.kr/handle/201004/128611
DOI
10.1016/j.cossms.2012.10.004
Appears in Collections:
KIST Article > 2012
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