Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells

Authors
Lee, Ji HwanLee, WoojungLee, SeungyongJung, YujungPark, Soon-HyeChoi, PiljuKim, Su-NamHam, JungyeobKang, Ki Sung
Issue Date
2012-09-01
Publisher
Pergamon Press Ltd.
Citation
Bioorganic & Medicinal Chemistry Letters, v.22, no.17, pp.5475 - 5479
Abstract
The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg(2), Rg(6) and F-4 by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage. (C) 2012 Elsevier Ltd. All rights reserved.
Keywords
RADICAL SCAVENGING ACTIVITY; ANTIOXIDATIVE ACTIVITIES; INHIBITION; RADICAL SCAVENGING ACTIVITY; ANTIOXIDATIVE ACTIVITIES; INHIBITION; Maillard reaction; Ginsenoside Re; Oxidative stress; Nephrotoxicity; Heat-processing
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/128882
DOI
10.1016/j.bmcl.2012.07.018
Appears in Collections:
KIST Article > 2012
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