DSpace at KISTKIST Article2012

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dc.contributor.authorKim, Taejung-
dc.contributor.authorLee, Woojung-
dc.contributor.authorJeong, Kyu Hyuk-
dc.contributor.authorSong, Jung Ho-
dc.contributor.authorPark, Soon-Hye-
dc.contributor.authorChoi, Pilju-
dc.contributor.authorKim, Su-Nam-
dc.contributor.authorLee, Seokjoon-
dc.contributor.authorHam, Jungyeob-
dc.date.accessioned2024-01-20T14:32:46Z-
dc.date.available2024-01-20T14:32:46Z-
dc.date.created2022-01-10-
dc.date.issued2012-06-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129145-
dc.description.abstractAmorphastilbol (APH-1), isolated from a Robinia pseudoacacia var. umbraculifer seed extract, is a biologically interesting natural trans-stilbene compound with dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist activity. After total synthesis of APH-1 and its derivatives by Pd-catalyzed Suzuki-Miyaura cross-coupling of a common (E)-styryl bromide intermediate and various aromatic trifluoroborate compounds, we biologically evaluated APH-2-APH-12 for PPAR agonist activity. APH-4 and APH-11 were effective PPAR alpha/gamma transcriptional activators, compared with APH-1. Therefore, we suggest that APH-4 and APH-11 are novel dual PPAR alpha/gamma agonists and are potentially useful for treating type 2 diabetes by enhancing glucose and lipid metabolism. (C) 2012 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectPOMEGRANATE FLOWER-
dc.subjectINSULIN-RESISTANCE-
dc.subjectMULTIMODAL DRUGS-
dc.subjectACTIVATION-
dc.subjectGAMMA-
dc.subjectTRIGLYCERIDES-
dc.subjectHYPERGLYCEMIA-
dc.subjectMODULATORS-
dc.subjectPREVENTS-
dc.subjectEXTRACT-
dc.titleTotal synthesis and dual PPAR alpha/gamma agonist effects of Amorphastilbol and its synthetic derivatives-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2012.04.062-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.22, no.12, pp.4122 - 4126-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume22-
dc.citation.number12-
dc.citation.startPage4122-
dc.citation.endPage4126-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000304484600055-
dc.identifier.scopusid2-s2.0-84861572684-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPOMEGRANATE FLOWER-
dc.subject.keywordPlusINSULIN-RESISTANCE-
dc.subject.keywordPlusMULTIMODAL DRUGS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusGAMMA-
dc.subject.keywordPlusTRIGLYCERIDES-
dc.subject.keywordPlusHYPERGLYCEMIA-
dc.subject.keywordPlusMODULATORS-
dc.subject.keywordPlusPREVENTS-
dc.subject.keywordPlusEXTRACT-
dc.subject.keywordAuthorNatural product-
dc.subject.keywordAuthorAmorphastilbol-
dc.subject.keywordAuthorType 2 diabetes-
dc.subject.keywordAuthorDual PPAR alpha/gamma agonists-
dc.subject.keywordAuthorSuzuki-Miyaura cross-coupling-
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