Thermosensitive/magnetic poly(organophosphazene) hydrogel as a long-term magnetic resonance contrast platform

Authors
Kim, Jang IlChun, ChangJuKim, BoraHong, Ji MinCho, Jung-KyoLee, Seung HoonSong, Soo-Chang
Issue Date
2012-01
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.33, no.1, pp.218 - 224
Abstract
A thermosensitive/magnetic poly(organophosphazene) hydrogel (a magnetic hydrogel) was designed and synthesized for long-term magnetic resonance (MR) imaging. To turn a thermosensitive poly(organophosphazene) hydrogel (an original hydrogel) into a long-term MR contrast platform, cobalt ferrite (CoFe2O4) nanoparticles, which have hydrophobic surfaces, were bound to the original hydrogel via interactions between the hydrophobic surfaces of the nanoparticles and the L-isoleucine ethyl esters of the polymer. The magnetic hydrogel showed extremely low cytotoxicity and adequate magnetic properties for use in long-term MR imaging, in addition to possessing the same properties of the original hydrogel, such as viscosity, thermosensitivity, biodegradability, biocompatibility, a reversible sol-to-gel phase transition near body temperature, and injectability. The magnetic hydrogel was injected into a rat brain using stereotactic surgery. After the injection, the applicable potentiality as a long-term MR contrast platform was successfully estimated over 4-5 weeks. Consequently, it was shown that a magnetic hydrogel as a long-term MR contrast platform has the potential to be applied in a long-term theranostic hydrogel system. Furthermore, it is expected that this platform can be useful in the clinical field of incurable diseases due to either surgical difficulties or lethality, such as with brain tumors, when the platform is combined with therapeutic drugs for long-term MR theragnosis in further studies. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords
SUPERPARAMAGNETIC IRON-OXIDE; CONTROLLED-RELEASE; CANCER; DRUG; ANGIOGRAPHY; FERROGELS; RISKS; SUPERPARAMAGNETIC IRON-OXIDE; CONTROLLED-RELEASE; CANCER; DRUG; ANGIOGRAPHY; FERROGELS; RISKS; Phosphazene; Magnetic hydrogel; Contrast agents; MRI; Hydrophobic interaction; Long-term MR imaging
ISSN
0142-9612
URI
https://pubs.kist.re.kr/handle/201004/129692
DOI
10.1016/j.biomaterials.2011.09.033
Appears in Collections:
KIST Article > 2012
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