Acremostrictin, a Highly Oxygenated Metabolite from the Marine Fungus Acremonium strictum

Abstract

The novel natural product acremostrictin (1) was isolated from the culture broth of Acremonium strictum, a marine fungus collected from a Choristida sponge off the coast of Korea. Structurally, acremostrictin is a tricyclic lactone of an unprecedented skeletal class based on combined spectroscopic and X-ray crystallographic analyses. The new compound exhibited weak antibacterial and moderate antioxidant activities.