Selective peroxisome proliferator-activated receptor delta isosteric selenium agonists as potent anti-atherogenic agents in vivo

Authors
Chin, JungwookHong, Jun YoungLee, JaehwanHwang, HoosangKo, HyunsilChoi, HyukjaeHahn, DongyupKo, JaeyoungNam, Sang-JipTak, JungaeHam, JungyeobKang, Heonjoong
Issue Date
2010-12-15
Publisher
Pergamon Press Ltd.
Citation
Bioorganic & Medicinal Chemistry Letters, v.20, no.24, pp.7239 - 7242
Abstract
We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPAR delta-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPAR delta is a viable drug candidate for targeting and treating atherosclerosis. (C) 2010 Elsevier Ltd. All rights reserved.
Keywords
PPAR-DELTA; MOLECULAR MODIFICATION; ATHEROSCLEROSIS; CHOLESTEROL; SULFIDES; BIOISOSTERISM; BETA/DELTA; MODELS; HEART; MICE; PPAR-DELTA; MOLECULAR MODIFICATION; ATHEROSCLEROSIS; CHOLESTEROL; SULFIDES; BIOISOSTERISM; BETA/DELTA; MODELS; HEART; MICE; PPAR delta-selective ligand; Anti-atherogenic agents; Intestinal polyp formation
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/130824
DOI
10.1016/j.bmcl.2010.10.103
Appears in Collections:
KIST Article > 2010
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