Antioxidant and Aldo-keto reductase family 1 B10 inhibition activities of korean local plant extracts

Abstract

Aldo-keto reductase family 1 B10 (AKR1B10) has been considered as a potential cancer therapeutic target. Ethanol extracts prepared from 82 Korean local plants were examined for their antioxidant activity and inhibitory effects on recombinant human AKR1B10 (rhAKR1B10) in vitro. 21 extracts showed more than 80% of ABTS radical scavenging activity at 100 μg/mL and 11 extracts inhibited more than 50% of rhAKR1B10 activity at 10 μg/mL. Especially, 9 extracts showed potent inhibition on rhAKR1B10 activity compared with positive control tetramethylene glutaric acid.