DSpace at KISTKIST Article2009

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dc.contributor.authorYoon, Goo-
dc.contributor.authorLee, Woojung-
dc.contributor.authorKim, Su-Nam-
dc.contributor.authorCheon, Seung Hoon-
dc.date.accessioned2024-01-20T20:34:49Z-
dc.date.available2024-01-20T20:34:49Z-
dc.date.created2021-09-05-
dc.date.issued2009-09-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/132165-
dc.description.abstractCompounds (1-6) isolated from the CH2Cl2 extract of Glycyrrhiza inflata and semisynthetic licochalcone A derivatives (7-14) were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Licochalcones A (4) and E (6), each with an allyl group at position 5 in the B ring exhibited significant inhibitory effects. Licochalcone A derivative 7, the most potent among the series, had an IC50 value of 11.7 +/- 2.0 mu M, ca. twofold better than that of licochalcone A (4). (C) 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectISOPRENYLATED FLAVONOIDS-
dc.subjectERYTHRINA-MILDBRAEDII-
dc.subjectRETROCHALCONES-
dc.subjectLICOCHALCONE-
dc.subjectPTP1B-
dc.subjectBARK-
dc.titleInhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2009.07.054-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.19, no.17, pp.5155 - 5157-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume19-
dc.citation.number17-
dc.citation.startPage5155-
dc.citation.endPage5157-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000268863800059-
dc.identifier.scopusid2-s2.0-68349160572-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusISOPRENYLATED FLAVONOIDS-
dc.subject.keywordPlusERYTHRINA-MILDBRAEDII-
dc.subject.keywordPlusRETROCHALCONES-
dc.subject.keywordPlusLICOCHALCONE-
dc.subject.keywordPlusPTP1B-
dc.subject.keywordPlusBARK-
dc.subject.keywordAuthorGlycyrrhiza inflata-
dc.subject.keywordAuthorAllyl retrochalcone-
dc.subject.keywordAuthorLicochalcone A-
dc.subject.keywordAuthorSemisynthetic-
dc.subject.keywordAuthorProtein tyrosine phosphatase 1B-
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