Aminostyrylbenzofuran derivatives as potent inhibitors for A beta fibril formation

Authors
Byun, Ji HunKim, HyeYunKim, YoungSooMook-Jung, InheeKim, Dong JinLee, Won KooYoo, Kyung Ho
Issue Date
2008-10-15
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.20, pp.5591 - 5593
Abstract
The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for A beta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for A beta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50) = 0.07 and 0.08 mu M, respectively) than those of Curcumin (IC(50) = 0.80 mu M) and IMSB (IC(50) = 8.00 mu M) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation. (C) 2008 Elsevier Ltd. All rights reserved.
Keywords
ALZHEIMERS-DISEASE; AMYLOID PLAQUES; IMAGING AGENTS; PROTEIN; PROBES; BRAIN; ALZHEIMERS-DISEASE; AMYLOID PLAQUES; IMAGING AGENTS; PROTEIN; PROBES; BRAIN; Alzheimer' s disease; A beta 42 fibrils; aminostyrylbenzofurans; inhibitory activity
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/133050
DOI
10.1016/j.bmcl.2008.08.111
Appears in Collections:
KIST Article > 2008
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