Aminostyrylbenzofuran derivatives as potent inhibitors for A beta fibril formation
- Authors
- Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho
- Issue Date
- 2008-10-15
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.20, pp.5591 - 5593
- Abstract
- The synthesis of a novel series of aminostyrylbenzofuran derivatives 1a-w and their inhibitory activities for A beta fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for A beta fibril formation. Among them, compounds 1i and 1q exhibited excellent inhibitory activities (IC(50) = 0.07 and 0.08 mu M, respectively) than those of Curcumin (IC(50) = 0.80 mu M) and IMSB (IC(50) = 8.00 mu M) as reference compounds. Both compounds were selected as promising candidates for further biological evaluation. (C) 2008 Elsevier Ltd. All rights reserved.
- Keywords
- ALZHEIMERS-DISEASE; AMYLOID PLAQUES; IMAGING AGENTS; PROTEIN; PROBES; BRAIN; ALZHEIMERS-DISEASE; AMYLOID PLAQUES; IMAGING AGENTS; PROTEIN; PROBES; BRAIN; Alzheimer' s disease; A beta 42 fibrils; aminostyrylbenzofurans; inhibitory activity
- ISSN
- 0960-894X
- URI
- https://pubs.kist.re.kr/handle/201004/133050
- DOI
- 10.1016/j.bmcl.2008.08.111
- Appears in Collections:
- KIST Article > 2008
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.